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A model for corneal endothelial morphometry by diffraction
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
2006 (English)In: Progr. Biomed. Opt. Imaging Proc. SPIE, 2006Conference paper (Refereed)
Abstract [en]

As a part of an ongoing project on corneal endothelium morphometry by diffraction, a model for corneal endothelium simulation has been developed. The model has been developed in the mathematical programming language Matlab™. Images of corneal endothelium were simulated and the diffraction pattern of the image was calculated. The diffraction pattern was calculated for a series of endothelial images while varying important variables in the simulated image. This rendered the theoretical relationships between values of variables in the diffraction pattern and values of morphometric variables in the image. At this stage, the analysis focused on the expression of endothelial mean cell size and coefficient of variation in the diffraction pattern, respectively. As expected from diffraction theory, it was found that there is a direct linear relationship between mean cell size and distance between periodic variations in the diffraction pattern. We further found that the ratio between the intensity in the central maximum and the intensity in the first harmonic of the diffraction pattern was functionally depending on the variation in cell size. The current findings demonstrate that it is possible to theoretically determine average cell size and coefficient of variation of cell size in the diffraction pattern.

Place, publisher, year, edition, pages
, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ISSN 1605-7422 ; 6138
Keyword [en]
Cornea, Diffraction, Endothelium, Morphometry, Simulation, Cell culture, Computer programming languages, Computer simulation, Harmonic analysis, Image processing, Diffraction pattern, Ophthalmology
National Category
URN: urn:nbn:se:kth:diva-156331DOI: 10.1117/12.660023ISI: 000237708800016ScopusID: 2-s2.0-33745416010ISBN: 0819461814ISBN: 9780819461810OAI: diva2:766748
Ophthalmic Technologies XVI, 21-24 January 2006, San Jose, CA, USA

QC 20141128

Available from: 2014-11-28 Created: 2014-11-26 Last updated: 2014-11-28Bibliographically approved

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Bucht, CurryManneberg, Göran
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