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Mechanisms of agglomeration of molecular crystals in organic solvents
KTH, School of Chemical Science and Engineering (CHE), Chemical Engineering and Technology.
KTH, School of Chemical Science and Engineering (CHE), Chemical Engineering and Technology.
2005 (English)In: 16th International Symposium on Industrial Crystallization, September, 11 - 14, International Congress Center, Dresden, Germany, 2005, no 1901 I, 511-516 p.Conference paper, Published paper (Refereed)
Abstract [en]

The agglomeration of paracetamol has been investigated by fully seeded isothermal crystallization experiments operated at constant supersaturation. The particles from crystallization in ethanol, methyl ethyl ketone, water and acetone-water mixtures are characterized by image analysis and multivariate data evaluation. The number of crystals in each agglomerated particle is characterized and used as a measure of the degree of agglomeration. Surfaces of large, well grown paracetamol crystals have been characterised by contact angle measurements and the Lifshitz-van der Waals acid-base theory to determine the crystal-crystal adhesion energy. It is found that, beyond the effect of differences in liquid viscosity and crystal growth rate, there is a dependence of the degree of agglomeration on the solvent composition that can be correlated to the free energy of adhesion.

Place, publisher, year, edition, pages
2005. no 1901 I, 511-516 p.
Series
VDI - Berichte, ISSN 0083-5560 ; 1901
Keyword [en]
Agglomeration, Angle measurement, Characterization, Crystal growth, Crystallization, Image analysis, Organic solvents, Agglomerated particle, Isothermal crystallization, Methyl ethyl ketone (MEK), Paracetamol crystals, Molecular crystals
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-156666Scopus ID: 2-s2.0-27344452516ISBN: 3180919019 (print)OAI: oai:DiVA.org:kth-156666DiVA: diva2:768176
Conference
16th International Symposium on Industrial Crystallization 11th - 14th September 2005, International Congress Center Dresden, Germany
Note

QC 20141203

Available from: 2014-12-03 Created: 2014-12-02 Last updated: 2014-12-03Bibliographically approved

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