Mechanisms of agglomeration of molecular crystals in organic solvents
2005 (English)In: 16th International Symposium on Industrial Crystallization, September, 11 - 14, International Congress Center, Dresden, Germany, 2005, no 1901 I, 511-516 p.Conference paper (Refereed)
The agglomeration of paracetamol has been investigated by fully seeded isothermal crystallization experiments operated at constant supersaturation. The particles from crystallization in ethanol, methyl ethyl ketone, water and acetone-water mixtures are characterized by image analysis and multivariate data evaluation. The number of crystals in each agglomerated particle is characterized and used as a measure of the degree of agglomeration. Surfaces of large, well grown paracetamol crystals have been characterised by contact angle measurements and the Lifshitz-van der Waals acid-base theory to determine the crystal-crystal adhesion energy. It is found that, beyond the effect of differences in liquid viscosity and crystal growth rate, there is a dependence of the degree of agglomeration on the solvent composition that can be correlated to the free energy of adhesion.
Place, publisher, year, edition, pages
2005. no 1901 I, 511-516 p.
, VDI - Berichte, ISSN 0083-5560 ; 1901
Agglomeration, Angle measurement, Characterization, Crystal growth, Crystallization, Image analysis, Organic solvents, Agglomerated particle, Isothermal crystallization, Methyl ethyl ketone (MEK), Paracetamol crystals, Molecular crystals
IdentifiersURN: urn:nbn:se:kth:diva-156666ScopusID: 2-s2.0-27344452516ISBN: 3180919019OAI: oai:DiVA.org:kth-156666DiVA: diva2:768176
16th International Symposium on Industrial Crystallization 11th - 14th September 2005, International Congress Center Dresden, Germany
QC 201412032014-12-032014-12-022014-12-03Bibliographically approved