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Binning metagenomic contigs by coverage and composition
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-2467-008X
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab. Bioinformatics Infrastructure for Life Sciences (BILS), Sweden.
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2014 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 11, no 11, 1144-1146 p.Article in journal (Refereed) Published
Abstract [en]

Shotgun sequencing enables the reconstruction of genomes from complex microbial communities, but because assembly does not reconstruct entire genomes, it is necessary to bin genome fragments. Here we present CONCOCT, a new algorithm that combines sequence composition and coverage across multiple samples, to automatically cluster contigs into genomes. We demonstrate high recall and precision on artificial as well as real human gut metagenome data sets.

Place, publisher, year, edition, pages
2014. Vol. 11, no 11, 1144-1146 p.
Keyword [en]
Sequences, Genomes
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-157613DOI: 10.1038/NMETH.3103ISI: 000344580600021PubMedID: 25218180Scopus ID: 2-s2.0-84908597294OAI: oai:DiVA.org:kth-157613DiVA: diva2:771118
Funder
Swedish Research Council, 2011-5689Formas, 2009-1174Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20141212

Available from: 2014-12-12 Created: 2014-12-11 Last updated: 2017-12-05Bibliographically approved

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Alneberg, JohannesBjarnason, Brynjar Smáride Bruijn, InoAndersson, Anders F.
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