Binning metagenomic contigs by coverage and composition
2014 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 11, no 11, 1144-1146 p.Article in journal (Refereed) Published
Shotgun sequencing enables the reconstruction of genomes from complex microbial communities, but because assembly does not reconstruct entire genomes, it is necessary to bin genome fragments. Here we present CONCOCT, a new algorithm that combines sequence composition and coverage across multiple samples, to automatically cluster contigs into genomes. We demonstrate high recall and precision on artificial as well as real human gut metagenome data sets.
Place, publisher, year, edition, pages
2014. Vol. 11, no 11, 1144-1146 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:kth:diva-157613DOI: 10.1038/NMETH.3103ISI: 000344580600021PubMedID: 25218180ScopusID: 2-s2.0-84908597294OAI: oai:DiVA.org:kth-157613DiVA: diva2:771118
FunderSwedish Research Council, 2011-5689Formas, 2009-1174Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
QC 201412122014-12-122014-12-112014-12-12Bibliographically approved