Change search
ReferencesLink to record
Permanent link

Direct link
SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma
Show others and affiliations
2014 (English)In: Virchows Archiv, ISSN 0945-6317, E-ISSN 1432-2307, Vol. 465, no 6, 649-659 p.Article in journal (Refereed) Published
Abstract [en]

Gastric cancer is the second most common cause of cancer-related death worldwide, and the incidence of esophageal adenocarcinoma is rising. While some progress has been made in treatment strategies, overall survival remains very poor for patients with adenocarcinoma in the upper gastrointestinal tract. Special AT-rich sequence binding protein 1 (SATB1) is a global genome organizer that has been demonstrated to promote aggressive tumor behavior in several different types of cancer, including gastric cancer. The prognostic value of SATB1 expression in esophageal cancer has, however, not yet been described. In this study, expression of SATB1 was examined by immunohistochemistry on tissue microarrays prepared from tissue samples from 175 patients with adenocarcinoma of the esophagus, cardia, or stomach and containing normal tissue, intestinal metaplasia, primary tumors, and metastases. A well-validated antibody was used. We found SATB1 to be an independent prognostic factor in patients with a radically resected tumor, correlating with shorter overall survival as well as with shorter recurrence-free survival. SATB1 expression was also found to be significantly lower in primary tumors associated with intestinal metaplasia than those without intestinal metaplasia. This observation is of potential biological interest as it has been proposed that intestinal metaplasia-associated tumors constitute a less aggressive phenotype.

Place, publisher, year, edition, pages
2014. Vol. 465, no 6, 649-659 p.
Keyword [en]
SATB1, SATB2, Gastric adenocarcinoma, Esophageal adenocarcinoma, Prognosis
National Category
Cancer and Oncology
URN: urn:nbn:se:kth:diva-158397DOI: 10.1007/s00428-014-1667-6ISI: 000345598300005ScopusID: 2-s2.0-84914151513OAI: diva2:778261

QC 20150109

Available from: 2015-01-09 Created: 2015-01-07 Last updated: 2015-01-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Uhlén, Mathias
By organisation
Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLab
In the same journal
Virchows Archiv
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link