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Surface Modification of Biomaterials
KTH, School of Chemical Science and Engineering (CHE).
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Ytmodifiering av biomaterial (Swedish)
Abstract [en]

Poly (ε-caprolactone) (PCL) is one of the most important and biodegradable polymers widely used in various biomedical application such as scaffold materials and biodegradable vessel implants. However, the intrinsic hydrophobicity, poor resistance to non-specific adsorption of plasma proteins and platelets are the main unfavorable properties. Thus, well-defined controllable surface modification with hydrophilic polymers is one of the practical approaches to getting rid of un-desired attachment from biological media such as blood plasma. 

In this study, the grafting of three different functional water-soluble vinyl monomers from PCL film surface were investigated to enhance the hemocompatibility and anti-fouling property of PCL films. Efficiency and versatility of these two techniques compared in biological point of view.

The surface modification of PCL film was confirmed by ATR-FTIR, signifying the success of the surface grafting methods. Moreover, static water contact angle measurements were performed to characterize the wettability changes of grafted PCL film surface. Topographical surface changes examined via AFM images of spin-coated PCL on Si-wafers. BCA (bicinchoninic acid) protein assay was performed to determine the amount of BSA (bovine serum albumin) and fibrinogen attached to the grafted and neat PCL surfaces. SEM was used for monitoring the platelet adhesion on the surface.

The blood compatibility of the grafted PCL samples was evaluated by the protein adsorption and platelet adhesion to grafted surfaces. The result from platelet adhesion evaluation and protein test of grafted PCL films showed that the one grafted with P(Tris-AAm) via Surface initiated SET-LRP has the best non-fouling properties against blood proteins (BSA and fibrinogen) and platelet adhesion among other acrylamides.

Place, publisher, year, edition, pages
2014.
Keyword [en]
Hemocompatibility, Surface Initiated SET-LRP, photografting, poly(ε-caprolactone), protein adsorption, platelet adhesion
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-158568OAI: oai:DiVA.org:kth-158568DiVA: diva2:778384
Available from: 2015-01-09 Created: 2015-01-09 Last updated: 2017-08-30Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
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  • vancouver
  • Other style
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  • de-DE
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  • nn-NB
  • sv-SE
  • Other locale
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