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A microfluidic device to sort capsules by deformability: a numerical study
KTH, School of Engineering Sciences (SCI), Mechanics. KTH, Centres, SeRC - Swedish e-Science Research Centre. Laboratory of Fluid Mechanics and Instabilities, Switzerland .
KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, Centres, Nordic Institute for Theoretical Physics NORDITA. KTH, Centres, SeRC - Swedish e-Science Research Centre.ORCID iD: 0000-0002-6309-4652
KTH, Centres, Nordic Institute for Theoretical Physics NORDITA.ORCID iD: 0000-0001-6162-7112
KTH, School of Engineering Sciences (SCI), Mechanics. KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, Centres, SeRC - Swedish e-Science Research Centre.ORCID iD: 0000-0002-4346-4732
2014 (English)In: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 10, no 39, 7705-7711 p.Article in journal (Refereed) Published
Abstract [en]

Guided by extensive numerical simulations, we propose a microfluidic device that can sort elastic capsules by their deformability. The device consists of a duct embedded with a semi-cylindrical obstacle, and a diffuser which further enhances the sorting capability. We demonstrate that the device can operate reasonably well under changes in the initial position of the capsule. The efficiency of the device remains essentially unaltered under small changes of the obstacle shape (from semi-circular to semi-elliptic cross-section). Confinement along the direction perpendicular to the plane of the device increases its efficiency. This work is the first numerical study of cell sorting by a realistic microfluidic device.

Place, publisher, year, edition, pages
2014. Vol. 10, no 39, 7705-7711 p.
National Category
Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:kth:diva-158861DOI: 10.1039/c4sm01097cISI: 000344998500006Scopus ID: 2-s2.0-84907863556OAI: oai:DiVA.org:kth-158861DiVA: diva2:781466
Funder
Swedish e‐Science Research CenterSwedish Research CouncilEU, European Research Council
Note

QC 20150116

Available from: 2015-01-16 Created: 2015-01-12 Last updated: 2017-12-05Bibliographically approved

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Rorai, CeciliaMitra, DhrubadityaBrandt, Luca

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Soft Matter
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