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Synthesis and Characterization of Drug-Anchored Pluronic Micelles
KTH, School of Chemical Science and Engineering (CHE).
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Syntes och karakterisering av pluronic miceller med kovalent bundna läkemedel (Swedish)
Abstract [en]

Amphiphilic Pluronic block copolymer consisting of hydrophobic poly(propylene oxide) (PPO) and hydrophilic poly(ethylene oxide) (PEO) blocks has sparked promising effect in the area of drug delivery systems due to specific advantages over other drug carriers such as 1) biocompatibility and nontoxicity 2) ability to encapsulate water-insoluble drugs 3) possibility to promote its functions by modification. However, a deadly weak point of Pluronic-based drug carriers depends on the relatively weak hydrophobic driving force coming from PPO core to stabilize amphiphilic micelles, which may lead to the micelle disintegration and sudden release of drug after being injected into the bloodstream. In this project, an optimized micelle system with cancerous cell-targeting functionality by conjugated folic acid at the chain end of Pluronic F127 (or L35) together with improved stability through chemical attachment of quercetin on the chain end of Pluronic 10R5 was developed. Data from a series of characterization techniques indicated that quercetin-anchored mixed micelle systems (FF/PQ and LF/PQ) were successfully formed. Folic acid (as a targeting ligand for tumor cells) decorated the surface of the micelles and anti-cancer drug was located in the core. Meanwhile, these mixed micelle system possessed optimized properties in terms of stability, PDI and size.

Place, publisher, year, edition, pages
2014.
Keyword [en]
micelle, pluronic, folic acid, quercetin, amphiphilic
National Category
Polymer Technologies
Identifiers
URN: urn:nbn:se:kth:diva-159167OAI: oai:DiVA.org:kth-159167DiVA: diva2:782774
Available from: 2015-01-22 Created: 2015-01-22 Last updated: 2017-08-31Bibliographically approved

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