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Nano-Stereocomplexation of Polylactide (PLA) Spheres by Spray Droplet Atomization
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.ORCID iD: 0000-0002-5850-8873
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
2014 (English)In: Macromolecular rapid communications, ISSN 1022-1336, E-ISSN 1521-3927, Vol. 35, no 22, 1949-1953 p.Article in journal (Refereed) Published
Abstract [en]

A direct, efficient, and scalable method to prepare stereocomplexed polylactide (PLA)-based nanoparticles (NPs) is achieved. By an appropriate combination of fabrication parameters, NPs with controlled shape and crystalline morphology are obtained and even pure PLA stereocomplexes (PLASC) are successfully prepared using the spray-drying technology. The formed particles of varying D- and L-LA content have an average size of approximate to 400 nm, where the smallest size is obtained for PLA50, which has an equimolar composition of PLLA and PDLA in solution. Raman spectra of the particles show the typical shifts for PLASC in PLA50, and thermal analysis indicates the presence of pure stereocomplexation, with only one melting peak at 226 degrees C. Topographic images of the particles exhibit a single phase with different surface roughness in correlation with the thermal analysis. A high yield of spherically shaped particles is obtained. The results clearly provide a proficient method for achieving PLASC NPs that are expected to function as renewable materials in PLA-based nanocomposites and potentially as more stable drug delivery carriers.

Place, publisher, year, edition, pages
2014. Vol. 35, no 22, 1949-1953 p.
Keyword [en]
biodegradable, nanoparticles, polylactides, spray-drying, stereocomplexes
National Category
Polymer Technologies
URN: urn:nbn:se:kth:diva-158321DOI: 10.1002/marc.201400374ISI: 000345443600006OAI: diva2:783475

QC 20150126

Available from: 2015-01-26 Created: 2015-01-07 Last updated: 2015-11-17Bibliographically approved
In thesis
1. Towards a retro-structural design of degradable aliphatic polyester-based materials
Open this publication in new window or tab >>Towards a retro-structural design of degradable aliphatic polyester-based materials
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The increasing amount of accumulated plastic waste has led to a continuous search for degradable materials for use in a variety of applications. This eco-friendly approach contemplates the use of degradable alternatives to the inert polymers (the main components in plastics) used today and further engineering of their degradation pathways. The most extensively investigated group of degradable polymers is the poly(α-esters), due to their tailorable thermo-mechanical properties and degradability. However, degradation of these polymers can be undesirable or desirable depending on the time of occurrence. Thus, by controlling the degradation process, it is possible to predict and, consequently, tailor the materials’ lifetime for specific needs.Herein, a methodology to allow for a retro-structural design of degradable materials based on aliphatic polyesters is presented. Insights into the degradation behavior of the systems were obtained and further translated to different levels of structural designs to achieve desired macroscopic properties in terms of performance and degradability. Several combinational strategies based on polymer morphology, polymer structure and block design, were developed. As a result, homopolymers and block copolymers with projected degradation for different instances were created. Apart from bulk modifications in the material, it was shown that it was possible to tailor degradation pathways by means of specific interactions between polymer pairs in block copolymers and also in polymer blends. Furthermore, well-defined structure-property relationships are crucial when designing materials with specific degradability properties. In light of this, degradable polyester-based particles with tunable crystalline structures and, hence, physical properties, were developed. These particles proved to function as reinforcing agents in the creation of “green” homocomposites. These composites are promising alternatives in the search for materials that are completely degradable and sustainable.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2015. 95 p.
TRITA-CHE-Report, ISSN 1654-1081 ; 2015:62
Hydrolysis, polyesters, polylactide, hydrophobicity, crystallinity, miscibility, nanoparticles, stereocomplex, homocomposites
National Category
Polymer Chemistry
Research subject
urn:nbn:se:kth:diva-177187 (URN)978-91-7595-748-7 (ISBN)
Public defence
2015-12-11, Kollegiesalen, Brinellvägen 2, KTH, Stockholm, 13:30 (English)

QC 20151117

Available from: 2015-11-17 Created: 2015-11-17 Last updated: 2015-11-17Bibliographically approved

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Arias, VeluskaOdelius, KarinAlbertsson, Ann-Christine
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