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Biocompatible near-infrared fluorescent nanoparticles for macro and microscopic in vivo functional bioimaging
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
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2014 (English)In: Biomedical Optics Express, ISSN 2156-7085, E-ISSN 2156-7085, Vol. 5, no 11, 4076-4088 p.Article in journal (Refereed) Published
Abstract [en]

Near-infrared (NIR) imaging technology has been widely used for biomedical research and applications, since it can achieve deep penetration in biological tissues due to less absorption and scattering of NIR light. In our research, polymer nanoparticles with NIR fluorophores doped were synthesized. The morphology, absorption/emission features and chemical stability of the fluorescent nanoparticles were characterized, separately. NIR fluorescent nanoparticles were then utilized as bright optical probes for macro in vivo imaging of mice, including sentinel lymph node (SLN) mapping, as well as distribution and excretion monitoring of nanoparticles in animal body. Furthermore, we applied the NIR fluorescent nanoparticles in in vivo microscopic bioimaging via a confocal microscope. Under the 635 nm-CW excitation, the blood vessel architecture in the ear and the brain of mice, which were administered with nanoparticles, was visualized very clearly. The imaging depth of our one-photon microscopy, which was assisted with NIR fluorescent nanoprobes, can reach as deep as 500 mu m. Our experiments show that NIR fluorescent nanoparticles have great potentials in various deep-tissue imaging applications.

Place, publisher, year, edition, pages
2014. Vol. 5, no 11, 4076-4088 p.
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-158831DOI: 10.1364/BOE.5.004076ISI: 000344939400025Scopus ID: 2-s2.0-84942368692OAI: oai:DiVA.org:kth-158831DiVA: diva2:783541
Note

QC 20150126

Available from: 2015-01-26 Created: 2015-01-12 Last updated: 2017-12-05Bibliographically approved

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Chu, LiliangWang, ShaoweiLi, KanghuiQian, Jun
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