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Strain assessment in the carotid artery wall using ultrasound speckle tracking: validation in a sheep model.
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. University of Leuven, Belgium .ORCID iD: 0000-0002-5795-9867
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2015 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 60, no 3, 1107- p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to validate carotid artery strain assessment in-vivo using ultrasound speckle tracking. The left carotid artery of five sheep was exposed and sonomicrometry crystals were sutured onto the artery wall to obtain reference strain. Ultrasound imaging was performed at baseline and stress, followed by strain estimation using an in-house speckle tracking algorithm tuned for vascular applications. The correlation between estimated and reference strain was r = 0.95 (p < 0.001) and r = 0.87 (p < 0.01) for longitudinal and circumferential strain, respectively. Moreover, acceptable limits of agreement were found in Bland-Altman analysis (longitudinally: -0.15 to 0.42%, circumferentially: -0.54 to 0.50%), which demonstrates the feasibility of estimating carotid artery strain using ultrasound speckle tracking. However, further studies are needed to test the algorithm on human in-vivo data and to investigate its potential to detect subclinical cardiovascular disease and characterize atherosclerotic plaques.

Place, publisher, year, edition, pages
2015. Vol. 60, no 3, 1107- p.
Keyword [en]
carotid artery, sheep model, sonomicrometry, strain estimation, ultrasound speckle tracking
National Category
Medical Image Processing
URN: urn:nbn:se:kth:diva-159739DOI: 10.1088/0031-9155/60/3/1107ISI: 000349438400017PubMedID: 25586239ScopusID: 2-s2.0-84921033465OAI: diva2:787183

QC 20150210

Available from: 2015-02-09 Created: 2015-02-09 Last updated: 2015-03-25Bibliographically approved

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