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Tissue-based map of the human proteome
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.ORCID iD: 0000-0001-8993-048X
KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-0198-7137
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
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2015 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 347, no 6220, 1260419- p.Article in journal (Refereed) Published
Abstract [en]

Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.

Place, publisher, year, edition, pages
2015. Vol. 347, no 6220, 1260419- p.
Keyword [en]
isoprotein, membrane protein, protein, proteome, tumor protein
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-160035DOI: 10.1126/science.1260419ISI: 000348225800036PubMedID: 25613900Scopus ID: 2-s2.0-84925582323OAI: oai:DiVA.org:kth-160035DiVA: diva2:788319
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut and Alice Wallenberg Foundation
Note

QC 20150216

Available from: 2015-02-13 Created: 2015-02-13 Last updated: 2017-12-04Bibliographically approved

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Uhlén, MathiasFagerberg, LinnOksvold, PerLundberg, EmmaSzigyarto, Cristina Al-KhaliliHober, SophiaTegel, HannaRockberg, JohanSchwenk, Jochen M

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Uhlén, MathiasFagerberg, LinnHallström, Björn MOksvold, PerSivertsson, ÅsaSjöstedt, EvelinaLundberg, EmmaSzigyarto, Cristina Al-KhaliliOdeberg, JacobTakanen, Jenny OttossonHober, SophiaAlm, ToveBerling, HolgerTegel, HannaRockberg, JohanNilsson, PeterSchwenk, Jochen MHamsten, Maricavon Feilitzen, KalleForsberg, MattiasPersson, LukasJohansson, FredricZwahlen, Martin
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Science for Life Laboratory, SciLifeLabProteomics and Nanobiotechnology
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