Molecular dynamics simulations indicate that DNA bases using graphene nanopores can be identified by their translocation times
2015 (English)In: RSC Advances, ISSN 2046-2069, Vol. 5, no 13, 9389-9395 p.Article in journal (Refereed) Published
The improvement of the resolution of DNA sequencing by nanopore technology is very important for its real-life application. In this paper, we report our work on using molecular dynamics simulation to study the dependence of DNA sequencing on the translocation time of DNA through a graphene nanopore, using the single-strand DNA fragment translocation through graphene nanopores with diameters down to similar to 2 nm as examples. We found that A, T, C, and G could be identified by the difference in the translocation time between different types of nucleotides through 2 nm graphene nanopores. In particular, the recognition of the graphene nanopore for different nucleotides can be greatly enhanced in a low electric field. Our study suggests that the recognition of a graphene nanopore by different nucleotides is the key factor for sequencing DNA by translocation time. Our study also indicates that the surface of a graphene nanopore can be modified to increase the recognition of nucleotides and to improve the resolution of DNA sequencing based on the DNA translocation time with a suitable electric field.
Place, publisher, year, edition, pages
2015. Vol. 5, no 13, 9389-9395 p.
IdentifiersURN: urn:nbn:se:kth:diva-160405DOI: 10.1039/c4ra12530dISI: 000347976500011ScopusID: 2-s2.0-84921318920OAI: oai:DiVA.org:kth-160405DiVA: diva2:790373
QC 201502242015-02-242015-02-192015-02-24Bibliographically approved