Release of quercetin from micellar nanoparticles with saturated and unsaturated core forming polyesters - A combined computational and experimental study
2015 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, Vol. 46, 417-426 p.Article in journal (Refereed) Published
Computational and experimental studies were combined to obtain new insight into the widely reported anomalous release mechanism of hydrophobic drug (quercetin) from polymeric micellar nanopartides. Saturated and unsaturated amphiphilic triblock copolymers from monomethoxy polyethylene glycol (mPEG), poly(butylene adipate) (PBA) and poly(cis-2-butene adipate) (PCBA) (mPEG-PBA-mPEG and mPEG-PCBA-mPEG) were utilized as model polymers to specify the contribution of polymer-micelle degradation and polymer-drug interactions on the observed differences in the release rates by applicable computational investigation and experimental evaluations. Monitoring the size of the micelles through the releasing process together with hydrolytic degradation studies of the core forming polymers proved that the contribution of polymer hydrolysis and micelle degradation on the observed differences in the release rates during the release time window was minimal. The compatibility between quercetin and the core forming polymer is another factor influencing the drug encapsulation and the relative release rate and it was therefore investigated theoretically (using density functional theory (DFT) at B3LYP/6-311(++)G level of theory) and experimentally (FT-IR imaging). The drug-polymer interactions in the core were shown to be much more important than the polymer and/or micelle swelling-dissociation-degradation processes under the studied conditions.
Place, publisher, year, edition, pages
2015. Vol. 46, 417-426 p.
Micellar nanoparticles, Unsaturated polyesters, Drug-polymer interactions, Density functional theory, Hydrogen bonding
Textile, Rubber and Polymeric Materials
IdentifiersURN: urn:nbn:se:kth:diva-160403DOI: 10.1016/j.msec.2014.10.059ISI: 000347757100054ScopusID: 2-s2.0-84908403070OAI: oai:DiVA.org:kth-160403DiVA: diva2:790402
QC 201502242015-02-242015-02-192015-02-24Bibliographically approved