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Sustained prognostic implications of newly detected glucose abnormalities in patients with acute myocardial infarction: Longterm follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort
KTH, School of Architecture and the Built Environment (ABE), Transport Science, Transport planning, economics and engineering.ORCID iD: 0000-0001-7606-8771
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2015 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 12, no 1, 23-32 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate long-term prognostic importance of newly discovered glucose disturbances in patients with acute myocardial infarction (AMI). Methods: During 1998-2001, consecutive patients with AMI (n=167) and healthy controls (n=184) with no previously known diabetes were investigated with an oral glucose tolerance test (OGTT). Patients and controls were separately followed up for cardiovascular events (first of cardiovascular mortality/AMI/stroke/heart failure) during a decade. Results: In all, 68% of the patients and 35% of the controls had newly detected abnormal glucose tolerance (AGT). Cardiovascular event (n=72, p=0.0019) and cardiovascular mortality (n=31, p=0.031) were more frequent in patients with newly detected AGT. Regarding patients, a Cox proportional-hazard regression analysis identified AGT (hazard ratio (HR): 2.30; 95% confidence interval (CI): 1.24-4.25; p=0.008) and previous AMI (HR: 2.39; CI: 1.31-4.35; p=0.004) as prognostically important. Conclusion: An OGTT at discharge after AMI disclosed a high proportion of patients with previously unknown AGT which had a significant and independent association with long-term prognosis.

Place, publisher, year, edition, pages
2015. Vol. 12, no 1, 23-32 p.
Keyword [en]
Myocardial infarction, prognosis, diabetes, impaired glucose tolerance, oral glucose tolerance test
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:kth:diva-160053DOI: 10.1177/1479164114551746ISI: 000346345200003Scopus ID: 2-s2.0-84916908631OAI: oai:DiVA.org:kth-160053DiVA: diva2:793136
Funder
Swedish Heart Lung Foundation
Note

QC 20150306

Available from: 2015-03-06 Created: 2015-02-13 Last updated: 2017-12-04Bibliographically approved

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