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Coupled Diffusion in Lipid Bilayers upon Close Approach
KTH, School of Engineering Sciences (SCI), Theoretical Physics.
KTH, School of Engineering Sciences (SCI), Theoretical Physics, Theoretical & Computational Biophysics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-2734-2794
2015 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 137, no 2, 708-714 p.Article in journal (Refereed) Published
Abstract [en]

Biomembrane interfaces create regions of slowed water dynamics in their vicinity. When two lipid bilayers come together, this effect is further accentuated, and the associated slowdown can affect the dynamics of larger-scale processes such as membrane fusion. We have used molecular dynamics simulations to examine how lipid and water dynamics are affected as two lipid bilayers approach each other. These two interacting fluid systems, lipid and water, both slow and become coupled when the lipid membranes are separated by a thin water layer. We show in particular that the water dynamics become glassy, and diffusion of lipids in the apposed leaflets becomes coupled across the water layer, while the outer leaflets remain unaffected. This dynamic coupling between bilayers appears mediated by lipid-water-lipid hydrogen bonding, as it occurs at bilayer separations where water-lipid hydrogen bonds become more common than water-water hydrogen bonds. We further show that such coupling occurs in simulations of vesicle-vesicle fusion prior to the fusion event itself. Such altered dynamics at membrane-membrane interfaces may both stabilize the interfacial contact and slow fusion stalk formation within the interface region.

Place, publisher, year, edition, pages
2015. Vol. 137, no 2, 708-714 p.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-161134DOI: 10.1021/ja508803dISI: 000348483400035PubMedID: 25535654Scopus ID: 2-s2.0-84921497340OAI: oai:DiVA.org:kth-161134DiVA: diva2:796647
Funder
The Swedish Foundation for International Cooperation in Research and Higher Education (STINT), IG2011-2072Swedish Research CouncilSwedish Foundation for Strategic Research Swedish National Infrastructure for Computing (SNIC)
Note

QC 20150319

Available from: 2015-03-19 Created: 2015-03-09 Last updated: 2017-12-04Bibliographically approved

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Lindahl, Erik

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