Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
KTH, School of Biotechnology (BIO), Industrial Biotechnology. Greifswald University, Germany.
KTH, School of Biotechnology (BIO), Industrial Biotechnology.ORCID iD: 0000-0003-3073-5641
Show others and affiliations
2015 (English)In: Biotechnology Advances, ISSN 0734-9750, E-ISSN 1873-1899, Vol. 33, no 5, 566-604 p.Article in journal (Refereed) Published
Abstract [en]

In this review we analyse structure/sequence-function relationships for the superfamily of PLP-dependent enzymes with special emphasis on class III transaminases. Amine transaminases are highly important for applications in biocatalysis in the synthesis of chiral amines. In addition, other enzyme activities such as racemases or decarboxylases are also discussed. The substrate scope and the ability to accept chemically different types of substrates are shown to be reflected in conserved patterns of amino acids around the active site. These findings are condensed in a sequence-function matrix, which facilitates annotation and identification of biocatalytically relevant enzymes and protein engineering thereof.

Place, publisher, year, edition, pages
2015. Vol. 33, no 5, 566-604 p.
Keyword [en]
Annotation, Biocatalysis, Bioinformatics, Enzyme discovery, PLP-dependent enzymes, Protein function, Transaminase
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-162120DOI: 10.1016/j.biotechadv.2014.12.012ISI: 000358467500011PubMedID: 25575689Scopus ID: 2-s2.0-84931009357OAI: oai:DiVA.org:kth-162120DiVA: diva2:797083
Funder
EU, FP7, Seventh Framework Programme, 289350
Note

QC 20150827

Available from: 2015-03-22 Created: 2015-03-22 Last updated: 2017-12-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Authority records BETA

Land, HenrikBerglund, Per

Search in DiVA

By author/editor
Steffen-Munsberg, FabianLand, HenrikBerglund, Per
By organisation
Industrial Biotechnology
In the same journal
Biotechnology Advances
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 91 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf