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Planar nanoneedles on-chip for intracellular measurements
KTH, School of Electrical Engineering (EES), Signal Processing. University of Twente, Netherlands .
2005 (English)In: Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Transducers Research Foundations, 2005, Vol. 1, 400-402 p.Conference paper (Refereed)
Abstract [en]

We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60-cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.

Place, publisher, year, edition, pages
Transducers Research Foundations, 2005. Vol. 1, 400-402 p.
Keyword [en]
Intracellular, Micro-machining, Nanofluidics, Nanoneedles
National Category
Other Engineering and Technologies
URN: urn:nbn:se:kth:diva-163625ScopusID: 2-s2.0-84902521849ISBN: 0974361119ISBN: 9780974361116OAI: diva2:801535
9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005, Boston, MA, United States, 9 October 2005 through 13 October 2005

QC 20150409

Available from: 2015-04-09 Created: 2015-04-09 Last updated: 2015-04-09Bibliographically approved

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