Method of affinity separation and ligands for use therein
1998 (English)Patent (Other (popular science, discussion, etc.))
Methods of affinity separation wherein the affinity ligand is an immobilized proteinaceous ligand wherein one or more of its asparagine (Asn) residues has been modified. Methods of making a stabilized combinatorial protein by a) modification of Asn residues within a protein molecule to increase stability of the protein in alkaline conditions, and b) randomization of a protein molecule to modify its binding characteristics, and combinatorial proteins wherein in a step separate from the randomization step, the stability of the protein in alkaline conditions has been increased by modifying one or more of its Asn residues.
Place, publisher, year, edition, pages
IdentifiersURN: urn:nbn:se:kth:diva-164256OAI: oai:DiVA.org:kth-164256DiVA: diva2:805027
US 6831161B1 (2004-12-14)
NO 323994 B1 (2007-07-30); CA 2347960 C (2008-08-05); JP 04801258 B2 (2011-10-26); CA 2633345 C (2013-02-26)2015-04-142015-04-142015-04-17Bibliographically approved