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Blood cells separation in spiral microchannels
KTH, School of Engineering Sciences (SCI), Applied Physics. Harvard Medical School, United States .
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2009 (English)In: Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2009, 1222-1224 p.Conference paper, Published paper (Refereed)
Abstract [en]

As major players in our defense system, white blood cells (WBCs) are essential for immunological tests. However, WBCs exist at low concentration in blood samples, typically less than 0.5% of blood cells, and separation or enrichment of leukocytes is therefore a critical initial step in many biological experiments. This paper reports a novel method, based on differential inertial focusing, for separating blood cells in high throughput fashion (volumetric flow rates >2 ml/min). In this method, inherent hydrodynamic forces developed in flow through curved channels force cells to migrate over streamlines and focus laterally in equilibrium positions based on size.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2009. 1222-1224 p.
Keyword [en]
Cells, Biological experiments, Cell separation, Equilibrium positions, Hydrodynamic forces, Low concentrations, Spiral, Volumetric flow rate, White blood cells, Blood
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-164539Scopus ID: 2-s2.0-84901791682ISBN: 9780979806421 (print)OAI: oai:DiVA.org:kth-164539DiVA: diva2:806276
Conference
13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, 1 November 2009 through 5 November 2009, Jeju, South Korea
Note

QC 20150420

Available from: 2015-04-20 Created: 2015-04-17 Last updated: 2015-04-20Bibliographically approved

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