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Novel bioassay system for single cells
KTH, School of Biotechnology (BIO), Nano Biotechnology (closed 20130101).
2009 (English)In: Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2009, 1171-1173 p.Conference paper, Published paper (Refereed)
Abstract [en]

In this paper, we propose a novel bioassay system consisting of an active microfluidic device integrated on a microwell plate for high throughput single-cell analysis. Firstly, a CFD (computational fluid dynamics) simulation is performed to determine flow fields in order to assess how fluid flow reaches cells cultured in the wells in the microwell plate. It is then confirmed that the cells are appropriately stained with Calcein AM by fluid flow generated by magnetically driven micropumps. The proposed bioassay system would be a powerful platform for single-cell characterization in a high throughput manner.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2009. 1171-1173 p.
Keyword [en]
Biophysics, Cells, Computational fluid dynamics, Cytology, Flow of fluids, Microchannels, Microfluidics, Pumps, Throughput, Calcein, CFD (computational fluid dynamics), High throughput, Micro pump, Micro-fluidic devices, Microwell plates, Single cells, Singlecell analysis, Bioassay
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-164555Scopus ID: 2-s2.0-84901772016ISBN: 9780979806421 (print)OAI: oai:DiVA.org:kth-164555DiVA: diva2:806311
Conference
13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, 1 November 2009 through 5 November 2009, Jeju, South Korea
Note

QC 20150420

Available from: 2015-04-20 Created: 2015-04-17 Last updated: 2015-04-20Bibliographically approved

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