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Centrifugal microfluidic system for rapid, low-cost HIV diagnosis: CD4+ T-cell counting using an integrated DVD platform
KTH, School of Biotechnology (BIO), Nano Biotechnology (closed 20130101).ORCID iD: 0000-0001-5199-0663
KTH, School of Biotechnology (BIO), Nano Biotechnology (closed 20130101).
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2012 (English)In: Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Chemical and Biological Microsystems Society , 2012, 1942-1944 p.Conference paper, Published paper (Refereed)
Abstract [en]

HIV is a pandemic that currently threatens over 33 million lives worldwide and HIV/AIDS remains one of the major causes of death globally. The continued monitoring of the CD4+ T-lymphocytes count in HIV patients is necessary for proper treatment, although this testing is too expensive and complex for limited resource settings. We report on a novel integrated centrifugal (CD) microfluidic system for rapid and low-cost HIV diagnosis through automated counting of CD4+ T-cells for point-of-care applications. We demonstrate the integrated T-cell immunocapture and detection mechanism using a novel system comprised of a modified commercial DVD drive and polymer disc.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2012. 1942-1944 p.
Keyword [en]
Centrifugal microfluidics, HIV diagnostics, Immunocapture
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-165131Scopus ID: 2-s2.0-84901758262ISBN: 9780979806452 (print)OAI: oai:DiVA.org:kth-165131DiVA: diva2:807495
Conference
16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 28 October 2012 through 1 November 2012, Okinawa, Japan
Note

QC 20150423

Available from: 2015-04-23 Created: 2015-04-23 Last updated: 2015-04-23Bibliographically approved

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Citation style
  • apa
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  • ieee
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  • vancouver
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More styles
Language
  • de-DE
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  • en-US
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  • nn-NB
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  • Other locale
More languages
Output format
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  • asciidoc
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