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Characterization of natural killer cells' cytotoxic heterogeneity using an array of sono-cages
KTH, School of Engineering Sciences (SCI), Applied Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics.ORCID iD: 0000-0002-7023-4772
KTH, School of Engineering Sciences (SCI), Applied Physics.ORCID iD: 0000-0002-3996-9279
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2012 (English)In: Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Chemical and Biological Microsystems Society , 2012, 1555-1557 p.Conference paper, Published paper (Refereed)
Abstract [en]

Using a multi-well device as an array of sono-cages for single cell analysis, we quantify for the first time the heterogeneity of natural killer (NK) cells' cytotoxic response against cancer cells. We report a fraction of inactive NK cells within the tested population (36%), as well as the existence of few 'serial killers' that eliminate up to six targets during 4 hours. We also characterize the multi-well acoustic device in terms of trapping efficiency at different actuation voltages, using adherent and non-adherent cell lines. We show that the acoustic forces applied on the cells can be compared to forces of biological processes (i.e. cell adherence).

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2012. 1555-1557 p.
Keyword [en]
Cytotoxicity, Microchip, Multi-well, Natural killer cells, Ultrasound
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-165130Scopus ID: 2-s2.0-84901760779ISBN: 9780979806452 (print)OAI: oai:DiVA.org:kth-165130DiVA: diva2:807606
Conference
16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 28 October 2012 through 1 November 2012, Okinawa, Japan
Note

QC 20150424

Available from: 2015-04-24 Created: 2015-04-23 Last updated: 2015-04-24Bibliographically approved

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Ohlin, MathiasÖnfelt, Björn

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Christakou, Athanasia E.Ohlin, MathiasFrisk, ThomasÖnfelt, BjörnWiklund, Martin
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