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Integrated 'lab-on-a-transistor': With droplets-in-air for parallel nanoliter reactions
KTH, School of Biotechnology (BIO), Molecular Biotechnology (closed 20130101).
2012 (English)In: Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Chemical and Biological Microsystems Society , 2012, 1945-1947 p.Conference paper, Published paper (Refereed)
Abstract [en]

We aim to take 'lab-on-chip' technology further by introducing the concept of a 'lab-on-transistor'. In this methodology, laboratory operations, such as heating, cell lysis, and detection, are performed on a single transistor instead of on an entire microchip. To demonstrate this concept, we developed a heating technique that allows transistors to act as electrically addressable, individual heating units. We have coupled the transistor heaters with placement of sub-nanoliter droplets to create individual heated reaction volumes. Under this configuration transistors become highly localized heater/sensors capable of high-speed thermocycling (>25°C/s) of <1nL reactions with potential for electrical detection of biological analytes.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2012. 1945-1947 p.
Keyword [en]
Denaturation, Droplets, Electroporation, Field effect transistor, Parallel, PCR
National Category
Biological Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-165123Scopus ID: 2-s2.0-84901806606ISBN: 9780979806452 (print)OAI: oai:DiVA.org:kth-165123DiVA: diva2:807647
Conference
16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 28 October 2012 through 1 November 2012, Okinawa, Japan
Note

QC 20150424

Available from: 2015-04-24 Created: 2015-04-23 Last updated: 2015-04-24Bibliographically approved

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