Enhanced Schwann Cell Attachment and Alignment Using One-Pot “Dual Click” GRGDS and YIGSR Derivatized Nanofibers
2015 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 16, no 1, 357-363 p.Article in journal (Refereed) Published
Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by Schwann cell attachment and proliferation, and the inclusion of YIGSR with GRGDS alters the expression of the receptor for YIGSR. Additionally, aligned nanofibers act as a potential guidance cue by increasing the aspect ratio and aligning the actin filaments, which suggest that peptide-functionalized scaffolds would be useful to direct SCs for peripheral nerve regeneration.
Place, publisher, year, edition, pages
2015. Vol. 16, no 1, 357-363 p.
Textile, Rubber and Polymeric Materials
IdentifiersURN: urn:nbn:se:kth:diva-165335DOI: 10.1021/bm501552tISI: 000347864200036ScopusID: 2-s2.0-84920895366OAI: oai:DiVA.org:kth-165335DiVA: diva2:808042
QC 201504282015-04-272015-04-272015-04-28Bibliographically approved