Post-Electrospinning “Triclick” Functionalization of Degradable Polymer Nanofibers
2015 (English)In: ACS Macro Letters, Vol. 4, no 2, 207-213 p.Article in journal (Refereed) Published
4-Dibenzocyclooctynol (DIBO) was used as an initiator for the ring-opening copolymerization of ε-caprolactone and 1,4,8-trioxaspiro[4.6]-9-undecanone (TOSUO) resulting in a series of DIBO end-functionalized copolymers. Following deprotection of the ketone group, the polymers were derivatized with aminooxyl-containing compounds by oxime ligation. Mixtures of keto- and alkyne-derivatized polymers were co-electrospun into well-defined nanofibers containing three separate chemical handles. Strain-promoted azide alkyne cycloaddition (SPAAC), oxime ligation, and copper-catalyzed azide alkyne cycloaddition (CuAAC) were used to sequentially functionalize the nanofibers first with fluorescent reporters and then separately with bioactive Gly-Arg-Gly-Asp-Ser (GRGDS), BMP-2 peptide, and dopamine. This translationally relevant approach facilitates the straightforward derivatization of diverse bioactive molecules that can be controllably tethered to the surface of nanofibers.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2015. Vol. 4, no 2, 207-213 p.
Textile, Rubber and Polymeric Materials
IdentifiersURN: urn:nbn:se:kth:diva-165332DOI: 10.1021/mz500759nISI: 000349814100014ScopusID: 2-s2.0-84923171801OAI: oai:DiVA.org:kth-165332DiVA: diva2:808044
QC 201504282015-04-272015-04-272016-04-13Bibliographically approved