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Post-Electrospinning “Triclick” Functionalization of Degradable Polymer Nanofibers
University of Akron, United States .
University of Akron, United States .ORCID iD: 0000-0001-7304-6737
University of Akron, United States .
University of Akron, United States .
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2015 (English)In: ACS Macro Letters, E-ISSN 2161-1653, Vol. 4, no 2, 207-213 p.Article in journal (Refereed) Published
Abstract [en]

4-Dibenzocyclooctynol (DIBO) was used as an initiator for the ring-opening copolymerization of ε-caprolactone and 1,4,8-trioxaspiro[4.6]-9-undecanone (TOSUO) resulting in a series of DIBO end-functionalized copolymers. Following deprotection of the ketone group, the polymers were derivatized with aminooxyl-containing compounds by oxime ligation. Mixtures of keto- and alkyne-derivatized polymers were co-electrospun into well-defined nanofibers containing three separate chemical handles. Strain-promoted azide alkyne cycloaddition (SPAAC), oxime ligation, and copper-catalyzed azide alkyne cycloaddition (CuAAC) were used to sequentially functionalize the nanofibers first with fluorescent reporters and then separately with bioactive Gly-Arg-Gly-Asp-Ser (GRGDS), BMP-2 peptide, and dopamine. This translationally relevant approach facilitates the straightforward derivatization of diverse bioactive molecules that can be controllably tethered to the surface of nanofibers.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2015. Vol. 4, no 2, 207-213 p.
National Category
Textile, Rubber and Polymeric Materials
Identifiers
URN: urn:nbn:se:kth:diva-165332DOI: 10.1021/mz500759nISI: 000349814100014Scopus ID: 2-s2.0-84923171801OAI: oai:DiVA.org:kth-165332DiVA: diva2:808044
Note

QC 20150428

Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04Bibliographically approved

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Publisher's full textScopushttp://dx.doi.org/10.1021/mz500759n

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Hua, Geng

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