Estrogen receptor signaling during vertebrate development
2015 (English)In: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, ISSN 1874-9399, E-ISSN 1876-4320, Vol. 1849, no 2, 142-151 p.Article, review/survey (Refereed) Published
Estrogen receptors are expressed and their cognate ligands produced in all vertebrates, indicative of important and conserved functions. Through evolution estrogen has been involved in controlling reproduction, affecting both the development of reproductive organs and reproductive behavior. This review broadly describes the synthesis of estrogens and the expression patterns of aromatase and the estrogen receptors, in relation to estrogen functions in the developing fetus and child. We focus on the role of estrogens for the development of reproductive tissues, as well as non-reproductive effects on the developing brain. We collate data from human, rodent, bird and fish studies and highlight common and species-specific effects of estrogen signaling on fetal development. Morphological malformations originating from perturbed estrogen signaling in estrogen receptor and aromatase knockout mice are discussed, as well as the clinical manifestations of rare estrogen receptor alpha and aromatase gene mutations in humans.
Place, publisher, year, edition, pages
2015. Vol. 1849, no 2, 142-151 p.
Estrogen, Aromatase, Estrogen receptor, Reproductive development, Sex differentiation, Vertebrate development
Health Sciences Cell and Molecular Biology
Research subject SRA - Molecular Bioscience
IdentifiersURN: urn:nbn:se:kth:diva-165366DOI: 10.1016/j.bbagrm.2014.06.005ISI: 000349272700008PubMedID: 24954179ScopusID: 2-s2.0-84921023929OAI: oai:DiVA.org:kth-165366DiVA: diva2:808132
FunderSwedish Cancer Society
QC 201505122015-04-272015-04-272015-05-12Bibliographically approved