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Oestrogen receptors in breast cancer: basic mechanisms and clinical implications
University of Houston, United States .ORCID iD: 0000-0002-0602-2062
University of Houston, United States .
2013 (English)In: Ecancermedicalscience, ISSN 1754-6605, Vol. 7, 370- p.Article in journal (Refereed) Published
Abstract [en]

Since the discovery of the connection between ovarian hormones and breast cancer, endocrine therapy has been an integral adjuvant treatment for patients with hormone-dependent breast cancers. Oestrogen receptor (ER) plays a central role in mediating the effects of endogenous hormones and therapeutic agents. ER serves as a prognostic marker for responsiveness to endocrine therapy and is targeted either directly by selective oestrogen receptor modulators (SERMs) and pure antagonists or indirectly by aromatase inhibitors (AIs) that block oestrogen production. A significant number of ER-positive patients, however, fail to respond to therapy or develop resistance over time. This review focuses on the current understanding of ER functions and recent advances in genomic technologies and research that have provided a global perspective on hormone and ER activity and led to a number of significant discoveries, including the roles of co-regulatory factors and non-coding RNAs. Mechanistic insights into normal ER functions and therapeutic actions of SERMs and AIs will enable the development of better predictive markers and more effective target mechanisms and ultimately facilitate improvements in disease outcomes and patient survival.

Place, publisher, year, edition, pages
2013. Vol. 7, 370- p.
National Category
Cell and Molecular Biology Cancer and Oncology
Research subject
SRA - Molecular Bioscience
URN: urn:nbn:se:kth:diva-165367DOI: 10.3332/ecancer.2013.370PubMedID: 24222786ScopusID: 2-s2.0-84891804538OAI: diva2:808133

QC 20150428

Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2015-04-28Bibliographically approved

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