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Shear wave elastography plaque characterization with mechanical testing validation: a phantom study.
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden .ORCID iD: 0000-0002-2487-7400
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0002-9654-447X
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0003-1002-2070
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2015 (English)In: Physics in medicine and biology, Vol. 60, no 8, 3151-3174 p.Article in journal (Refereed) Published
Abstract [en]

Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with atherosclerotic plaque. Currently, clinical non-invasive ultrasound-based methods for plaque characterization are limited to visual assessment of plaque morphology and new quantitative methods are needed. In this study, shear wave elastography (SWE) was used to characterize hard and soft plaque mimicking inclusions in six common carotid artery phantoms by using phase velocity analysis in static and dynamic environments. The results were validated with mechanical tensile testing. In the static environment, SWE measured a mean shear modulus of 5.8±0.3kPa and 106.2±17.2kPa versus 3.3±0.5kPa and 98.3±3.4kPa measured by mechanical testing in the soft and hard plaques respectively. Furthermore, it was possible to measure the plaques' shear moduli throughout a simulated cardiac cycle. The results show good agreement between SWE and mechanical testing and indicate the possibility for in vivo arterial plaque characterization using SWE.

Place, publisher, year, edition, pages
2015. Vol. 60, no 8, 3151-3174 p.
National Category
Medical Image Processing
URN: urn:nbn:se:kth:diva-164418DOI: 10.1088/0031-9155/60/8/3151ISI: 000352525200013PubMedID: 25803520ScopusID: 2-s2.0-84927602186OAI: diva2:808218
Swedish Research CouncilVINNOVA, 2011-01365

QC 20150518

Available from: 2015-04-27 Created: 2015-04-17 Last updated: 2016-09-21Bibliographically approved
In thesis
1. Ultrasonic Methods for Quantitative Carotid Plaque Characterization
Open this publication in new window or tab >>Ultrasonic Methods for Quantitative Carotid Plaque Characterization
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cardiovascular diseases are the leading causes of death worldwide and improved diagnostic methods are needed for early intervention and to select the most suitable treatment for patients. Currently, carotid artery plaque vulnerability is typically determined by visually assessing ultrasound B-mode images, which is influenced by user-subjectivity. Since plaque vulnerability is correlated to the mechanical properties of the plaque, quantitative techniques are needed to estimate plaque stiffness as a surrogate for plaque vulnerability, which would reduce subjectivity during plaque assessment. The work in this thesis focused on three noninvasive ultrasound-based techniques to quantitatively assess plaque vulnerability and measure arterial stiffness. In Study I, a speckle tracking algorithm was validated in vitro to assess strain in common carotid artery (CCA) phantom plaques and thereafter applied in vivo to carotid atherosclerotic plaques where the strain results were compared to visual assessments by experienced physicians. In Study II, hard and soft CCA phantom plaques were characterized with shear wave elastography (SWE) by using phase and group velocity analysis while being hydrostatically pressurized followed by validating the results with mechanical tensile testing. In Study III, feasibility of assessing the stiffness of simulated plaques and the arterial wall with SWE was demonstrated in an ex vivo setup in small porcine aortas used as a human CCA model. In Study IV, SWE and pulse wave imaging (PWI) were compared when characterizing homogeneous CCA soft phantom plaques. The techniques developed in this thesis have demonstrated potential to characterize carotid artery plaques. The results show that the techniques have the ability to noninvasively evaluate the mechanical properties of carotid artery plaques, provide additional data when visually assessing B-mode images, and potentially provide improved diagnoses for patients suffering from cerebrovascular diseases.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2016. 70 p.
TRITA-STH : report, ISSN 1653-3836 ; 2016:08
Atherosclerosis, Cardiovascular Disease, Carotid Artery, Elasticity, ex vivo, in vivo, Phantom, Plaque, Polyvinyl Alcohol, Pulse Wave Imaging, Shear Wave Elastography, Speckle Tracking, Stroke, Ultrasound
National Category
Medical Image Processing
Research subject
Medical Technology
urn:nbn:se:kth:diva-192339 (URN)978-91-7729-085-8 (ISBN)
Public defence
2016-10-13, T2, Hälsovägen 11c, Huddinge, 15:05 (English)

Doctoral thesis in medical technology and medical sciences

QC 20160921

Available from: 2016-09-21 Created: 2016-09-09 Last updated: 2016-09-21Bibliographically approved

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Widman, ErikMaksuti, EliraLarsson, DavidBjallmark, AnnaLarsson, Matilda
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