Change search
ReferencesLink to record
Permanent link

Direct link
Calcium Signaling in Neocortical Development
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-9722-7425
Show others and affiliations
2015 (English)In: Developmental Neurobiology, ISSN 1932-8451, E-ISSN 1932-846X, Vol. 75, no 4, 360-368 p.Article in journal (Refereed) Published
Abstract [en]

The calcium ion (Ca2+) is an essential second messenger that plays a pivotal role in neurogenesis. In the ventricular zone (VZ) of the neocortex, neural stem cells linger to produce progenitor cells and subsequently neurons and glial cells, which together build up the entire adult brain. The radial glial cells, with their characteristic radial fibers that stretch from the inner ventricular wall to the outer cortex, are known to be the neural stem cells of the neocortex. Migrating neurons use these radial fibers to climb from the proliferative VZ in the inner part of the brain to the outer layers of the cortex, where differentiation processes continue. To establish the complex structures that constitute the adult cerebral cortex, proliferation, migration, and differentiation must be tightly controlled by various signaling events, including cytosolic Ca2+ signaling. During development, cells regularly exhibit spontaneous Ca2+ activity that stimulates downstream effectors, which can elicit these fundamental cell processes. Spontaneous Ca2+ activity during early neocortical development depends heavily on gap junctions and voltage dependent Ca2+ channels, whereas later in development neurotransmitters and synapses exert an influence. Here, we provide an overview of the literature on Ca2+ signaling and its impact on cell proliferation, migration, and differentiation in the neocortex. We point out important historical studies and review recent progress in determining the role of Ca2+ signaling in neocortical development. (c) 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 360-368, 2015

Place, publisher, year, edition, pages
2015. Vol. 75, no 4, 360-368 p.
National Category
URN: urn:nbn:se:kth:diva-164426DOI: 10.1002/dneu.22273ISI: 000351401900004PubMedID: 25652687ScopusID: 2-s2.0-84925016450OAI: diva2:808327
Swedish Research Council, 2009-3364, 2010-4392, 2013-3189Swedish Cancer Society, CAN 2013-802Linnaeus research environment CADICSKnut and Alice Wallenberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience

QC 20150428

Available from: 2015-04-28 Created: 2015-04-17 Last updated: 2015-04-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Fritz, Nicolas
By organisation
Cell PhysicsScience for Life Laboratory, SciLifeLab
In the same journal
Developmental Neurobiology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 19 hits
ReferencesLink to record
Permanent link

Direct link