Change search
ReferencesLink to record
Permanent link

Direct link
Synthesis of Multifunctional Cellulose Nanocrystals for Lectin Recognition and Bacterial Imaging
KTH, School of Chemical Science and Engineering (CHE), Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
University of Massachusetts, United States .
University of Massachusetts, United States .
Show others and affiliations
2015 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 16, no 4, 1426-1432 p.Article in journal (Refereed) Published
Abstract [en]

Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone fluorophore and carbohydrate ligands. The cellulose nanocrystals were subsequently applied in interaction studies with carbohydrate-binding proteins and in bacterial imaging. The results show that the functional cellulose nanocrystals could selectively recognize the corresponding cognate lectins. In addition, mannosylated nanocrystals were shown to selectively interact with FimH-presenting E. coli, as detected by TEM and confocal fluorescence microscopy. These glyconanomaterials provide a new application of cellulose nanocrystals in biorecognition and imaging.

Place, publisher, year, edition, pages
2015. Vol. 16, no 4, 1426-1432 p.
National Category
Organic Chemistry
URN: urn:nbn:se:kth:diva-165759DOI: 10.1021/acs.biomac.5b00227ISI: 000353006000038PubMedID: 25738860ScopusID: 2-s2.0-84927944680OAI: diva2:808756
Swedish Research CouncilSwedish Research Council Formas

QC 20150511

Available from: 2015-04-29 Created: 2015-04-29 Last updated: 2015-08-13Bibliographically approved
In thesis
1. Multifunctional Glyconanomaterials: Applications in Biorecognition and Drug Delivery
Open this publication in new window or tab >>Multifunctional Glyconanomaterials: Applications in Biorecognition and Drug Delivery
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis consists of three parts, which revolve around the fabrication of multifunctional glyconanomaterials (cellulose nanocrystals, chitin nanocrystals, mesoporous silica nanoparticles) and the development of their applications in biorecognition and nanomedicine.

Part one presents a detailed introduction to glyconanomaterials, focusing on cellulose nanocrystals, chitin nanocrystals and mesoporous silica nanoparticles, including their general preparations, properties and applications.

Part two demonstrates dually modified cellulose and chitin nanocrystals. They are prepared by TEMPO-mediated oxidation, followed by conjugation with a fluorescent dye and carbohydrate ligands. The two functional nanocrystals are applied in carbohydrate-lectin recognition and bacterial imaging as new types of glyconanomaterials.

Part three describes two types of drug delivery systems based on carbohydrate- conjugated mesoporous silica nanoparticles: the first type is a trehalose- functionalized nanoparticle which can selectively recognize mycobacteria, release antimicrobial drugs and kill them; the second type is a lectin-gated drug container, which can perform controlled delivery of drugs to cancer cells in response to glutathione.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2015. 70 p.
TRITA-CHE-Report, ISSN 1654-1081 ; 2015:28
glyconanomaterials, cellulose nanocrystals, chitin nanocrystals, mesoporous silica nanoparticles, lectin, biorecognition, drug delivery, bacteria, cytotoxicity, perfluorophenylazide, fluorescent dye, carbohydrate ligands.
National Category
Nano Technology
urn:nbn:se:kth:diva-171951 (URN)978-91-7595-570-4 (ISBN)
Public defence
2015-09-04, B2, Brinellvägen 23, KTH, Stockholm, 13:00 (English)

QC 20150813

Available from: 2015-08-13 Created: 2015-08-10 Last updated: 2015-08-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Zhou, JuanButchosa, NúriaZhou, QiYan, MingdiRamström, Olof
By organisation
ChemistryFibre and Polymer TechnologyWallenberg Wood Science CenterAlbanova VinnExcellence Center for Protein Technology, ProNova
In the same journal
Organic Chemistry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 85 hits
ReferencesLink to record
Permanent link

Direct link