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Design modification and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering
Loughborough University.
Loughborough University.
Loughborough University.
2015 (English)In: Bioprocess and biosystems engineering (Print), ISSN 1615-7591, E-ISSN 1615-7605, Vol. 38, no 7, 1423-1429 p.Article in journal (Refereed) Published
Abstract [en]

A systematic design of experiments (DOE) approach was used to optimize the perfusion process of a tri-axial bioreactor designed for translational tissue engineering exploiting mechanical stimuli and mechanotransduction. Four controllable design parameters affecting the perfusion process were identified in a cause–effect diagram as potential improvement opportunities. A screening process was used to separate out the factors that have the largest impact from the insignificant ones. DOE was employed to find the settings of the platen design, return tubing configuration and the elevation difference that minimise the load on the pump and variation in the perfusion process and improve the controllability of the perfusion pressures within the prescribed limits. DOE was very effective for gaining increased knowledge of the perfusion process and optimizing the process for improved functionality. It is hypothesized that the optimized perfusion system will result in improved biological performance and consistency.

Place, publisher, year, edition, pages
2015. Vol. 38, no 7, 1423-1429 p.
National Category
Engineering and Technology
URN: urn:nbn:se:kth:diva-165914DOI: 10.1007/s00449-015-1371-1ISI: 000355940900020ScopusID: 2-s2.0-84922495800OAI: diva2:809121

QC 20150708

Available from: 2015-04-30 Created: 2015-04-30 Last updated: 2015-07-08Bibliographically approved

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Hussein, Husnah
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