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Fabrication of Polylactide-Based Biodegradable Thermoset Scaffolds for Tissue Engineering Applications
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2013 (English)In: Macromolecular materials and engineering (Print), ISSN 1438-7492, E-ISSN 1439-2054, Vol. 298, no 1, 45-52 p.Article in journal (Refereed) Published
Abstract [en]

The fabrication of tissue engineering scaffolds based on the polymerization of crosslinked polylactide using leaching and batch foaming to generate well-controlled and interconnected biodegradable polymer scaffolds is reported. The scaffold fabrication parameters are studied in relation to the interpore connectivity, pore morphology, and structural stability of the crosslinked PLA scaffold. In vitro cell culture and in vitro degradation are used to analyze the biocompatibility and biodegradability of the scaffolds. The new crosslinked PLA thermoset scaffolds are highly suitable for bone tissue engineering applications due to their complex internal architecture, thermal stability, and biocompatibility.

Place, publisher, year, edition, pages
2013. Vol. 298, no 1, 45-52 p.
Keyword [en]
bone tissue engineering, crosslinked polylactide, degradation, hMSC adhesion
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-165918DOI: 10.1002/mame.201100436ISI: 000313254000006Scopus ID: 2-s2.0-84872085188OAI: oai:DiVA.org:kth-165918DiVA: diva2:809130
Note

QC 20150504

Available from: 2015-04-30 Created: 2015-04-30 Last updated: 2017-12-04Bibliographically approved

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