Fabrication of Polylactide-Based Biodegradable Thermoset Scaffolds for Tissue Engineering Applications
2013 (English)In: Macromolecular materials and engineering (Print), ISSN 1438-7492, E-ISSN 1439-2054, Vol. 298, no 1, 45-52 p.Article in journal (Refereed) Published
The fabrication of tissue engineering scaffolds based on the polymerization of crosslinked polylactide using leaching and batch foaming to generate well-controlled and interconnected biodegradable polymer scaffolds is reported. The scaffold fabrication parameters are studied in relation to the interpore connectivity, pore morphology, and structural stability of the crosslinked PLA scaffold. In vitro cell culture and in vitro degradation are used to analyze the biocompatibility and biodegradability of the scaffolds. The new crosslinked PLA thermoset scaffolds are highly suitable for bone tissue engineering applications due to their complex internal architecture, thermal stability, and biocompatibility.
Place, publisher, year, edition, pages
2013. Vol. 298, no 1, 45-52 p.
bone tissue engineering, crosslinked polylactide, degradation, hMSC adhesion
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:kth:diva-165918DOI: 10.1002/mame.201100436ISI: 000313254000006ScopusID: 2-s2.0-84872085188OAI: oai:DiVA.org:kth-165918DiVA: diva2:809130
QC 201505042015-04-302015-04-302015-05-04Bibliographically approved