Change search
ReferencesLink to record
Permanent link

Direct link
Perfusion Processes
KTH, School of Biotechnology (BIO), Industrial Biotechnology. (Cell Technology)ORCID iD: 0000-0002-5370-4621
2015 (English)In: Animal Cell Culture / [ed] Mohamed Al-Rubeai, Switzerland Springer: Springer , 2015, 407-443 p.Chapter in book (Refereed)
Abstract [en]

The interest for perfusion is increasing nowadays. This new focus has emerged from a synergy of a demand for disposable equipment and the availability of robust cell separation device, as well as the need for higher flexibility and lower investment cost. The cell separation devices mostly used today are based on filtration, i.e. alternating flow filtration, tangential flow filtration, spin-filter, or acceleration/gravity, i.e. inclined settler, centrifuge, acoustic settler. This paper gives an introduction to the basic concepts of perfusion and its practical implementation. It reviews the actual cell separation devices and describes the approaches used in the field to develop and optimize the perfusion processes.

Place, publisher, year, edition, pages
Switzerland Springer: Springer , 2015. 407-443 p.
, Cell Engineering, ISSN 1389-6946
Keyword [en]
perfusion, CHO, Chinese Hamster Ovary cells, mammalian cells, ATF, TFF, centritech, acoustic settler, inclined settler, perfusion rate
National Category
Bioprocess Technology
Research subject
URN: urn:nbn:se:kth:diva-166112DOI: 10.1007/978-3-319-10320-4_13ISBN: 978-3-319-10320-4OAI: diva2:809286

QC 20150508

Available from: 2015-05-01 Created: 2015-05-01 Last updated: 2015-05-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Chotteau, Veronique
By organisation
Industrial Biotechnology
Bioprocess Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 65 hits
ReferencesLink to record
Permanent link

Direct link