Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Dendritic hydrogels: From exploring various crosslinking chemistries to introducing functions and naturally abundant resources
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.ORCID iD: 0000-0002-3755-722X
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Coating Technology.ORCID iD: 0000-0002-9200-8004
2015 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 53, no 21, 2431-2439 p.Article in journal (Refereed) Published
Abstract [en]

Dendritic hydrogels from dendritic-linear-dendritic (DLD) block copolymers based on PEG and bis-MPA dendrons were constructed via UV-initiated thiol-ene, thiol-yne, CuAAC, and amine-NHS crosslinking chemistries. Stoichiometric ratio manipulations, prior to film formation, resulted in functional hydrogels with tuneable compressive moduli. The highest gel fractions for all networks were obtained at off-stoichiometric ratios with surplus of DLDs. Finally, sustainable networks were fabricated by amalgamating DLD, naturally abundant cellulose nanocrystal, and protein-based bovine serum albumin.

Place, publisher, year, edition, pages
2015. Vol. 53, no 21, 2431-2439 p.
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-166862DOI: 10.1002/pola.27750ISI: 000362372700001Scopus ID: 2-s2.0-84941803770OAI: oai:DiVA.org:kth-166862DiVA: diva2:812801
Note

Updated from manuscript to article.

QC 20151021

Available from: 2015-05-20 Created: 2015-05-20 Last updated: 2017-12-04Bibliographically approved
In thesis
1. Advanced Functional Thin Films and Networks towards Biological Applications
Open this publication in new window or tab >>Advanced Functional Thin Films and Networks towards Biological Applications
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Functional polymeric scaffolds have been employed in biological applications as several utilities, from nano-sized drug delivery systems to concrete implants. The progression in biological fields essentially relies on finding an appropriate material to fulfil the critical requirements for various types of applications with great potential for tuning functionality and mechanical properties. Therefore, the generation of new materials in extensive libraries is desirable for researchers. In this thesis, two main varieties of functional scaffolds have been constructed; these include i) periodic structure isoporous membranes and ii) three dimension (3D) crosslinked networks with programmable functionalities and mechanical properties. In the first case, a library of linear dendritic (LD) block copolymers was synthesised from biocompatible 2,2-bis(methylol)propionic acid (bis-MPA) dendrons and 2- hydroxyethyl methacrylate (HEMA) derivatives. These materials were successfully employed for the fabrication of isoporous membranes via the facile Breath Figure (BF) method. The dendritic periphery end groups control the manipulation of film morphology, as well as introduction of desired functionalities, either pre- or post- film formation. The introduction of azide functional group along the polymer backbone allows crosslinking reaction, which enhances the stability of the isoporous films. The stability towards temperature was improved from around its glass transition temperature (Tg) to 400 °C after crosslinking; simultaneously the porosity is maintained after immersion in the whole range of pH (1-14). These materials show great potential use as high performance isoporous membranes in futuristic applications such as micro-reactors, sensors and cell patterning platforms. In the second case, the facile fabrication of functional networks employs off-stoichiometric crosslinking, which resulted in residual reactive functional groups after film formation and networks with different crosslinking density. This straightforward off-stoichiometric concept is applied with commercially available materials and well-controlled dendritic-linear-dendritic (DLD) hybrid polymers, generating functional networks with different properties from high stiffness film to soft hydrogels. The network post-modification can be performed topologically and throughout the scaffold. Several crosslinking chemistries were employed for construction of hydrogels from DLD hybrid polymers. The Copper(I) Catalysed Azide-Alkyne Cycloaddition (CuAAC) click reaction results in hydrogels with higher compressive modulus compared to other hydrogels constructed from thiol-ene, thiol-yne and amine-N-hydroxysuccinimide (NHS) esters coupling methods with similar building blocks. These functional crosslinked networks are suitable for numerous applications including fabrication of microfluidic devices, cell culture platforms and bone adhesives.

 

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2015. 72 p.
Series
TRITA-CHE-Report, ISSN 1654-1081 ; 2015:23
National Category
Polymer Chemistry
Research subject
Chemistry
Identifiers
urn:nbn:se:kth:diva-166600 (URN)978-91-7595-552-0 (ISBN)
Public defence
2015-06-05, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:00 (English)
Opponent
Supervisors
Funder
VINNOVA
Note

QC 20150520

Available from: 2015-05-20 Created: 2015-05-12 Last updated: 2015-05-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Boujemaoui, AssyaMalkoch, Michael

Search in DiVA

By author/editor
Mongkhontreerat, SurinthraAndrén, Oliver C. J.Boujemaoui, AssyaMalkoch, Michael
By organisation
Coating Technology
In the same journal
Journal of Polymer Science Part A: Polymer Chemistry
Polymer Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 225 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf