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Mapping of Cortical Avalanches to the Striatum
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. KTH, School of Computer Science and Communication (CSC), Computational Science and Technology (CST). University of Freiburg, Germany.
National Institute of Mental Health, Bethesda, USA.
National Institute of Mental Health, Bethesda, USA.
KTH, School of Computer Science and Communication (CSC).ORCID iD: 0000-0002-0550-0739
2015 (English)In: Advances in Cognitive Neurodynamics, Springer Netherlands, 2015, 4, 291-297 p.Chapter in book (Refereed)
Abstract [en]

Neuronal avalanches are found in the resting state activity of the mammaliancortex. Here we studied whether and how cortical avalanches are mappedonto the striatal circuitry, the first stage of the basal ganglia. We first demonstrate using organotypic cortex-striatum-substantia nigra cultures from rat that indeed striatal neurons respond to cortical avalanches originating in superficial layers. We simultaneously recorded spontaneous local field potentials (LFPs) in the cortical and striatal tissue using high-density microelectrode arrays. In the cortex, spontaneous neuronal avalanches were characterized by intermittent spatiotemporal activity clusters with a cluster size distribution that followed a power law with exponent 1.5. In the striatum, intermittent spatiotemporal activity was found to correlate with cortical avalanches. However, striatal negative LFP peaks (nLFPs) did not showavalanche signatures, but formed a cluster size distribution that had a much steeper drop-off, i.e., lacked large spatial clusters that are commonly expected for avalanche dynamics. The underlying de-correlation of striatal activity could have its origin in the striatum through local inhibition and/or could result from a particular mapping in the corticostriatal pathway. Here we show, using modeling, that highly convergent corticostriatal projections can map spatially extended cortical activity into spatially restricted striatal regimes.

Place, publisher, year, edition, pages
Springer Netherlands, 2015, 4. 291-297 p.
Keyword [en]
Neuronal avalanches, Striatum, Cortico-striatal network, Cortex, Basal ganglia
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:kth:diva-168104DOI: 10.1007/978-94-017-9548-7_41ISI: 000380362800041ISBN: 978-94-017-9547-0 (print)OAI: oai:DiVA.org:kth-168104DiVA: diva2:814424
Note

QC 20150623

Available from: 2015-05-27 Created: 2015-05-27 Last updated: 2016-08-12Bibliographically approved

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Publisher's full texthttp://link.springer.com/chapter/10.1007%2F978-94-017-9548-7_41

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Hällgren Kotaleski, Jeanette

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