Mapping of Cortical Avalanches to the Striatum
2015 (English)In: Advances in Cognitive Neurodynamics, Springer Netherlands, 2015, 4, 291-297 p.Chapter in book (Refereed)
Neuronal avalanches are found in the resting state activity of the mammaliancortex. Here we studied whether and how cortical avalanches are mappedonto the striatal circuitry, the first stage of the basal ganglia. We first demonstrate using organotypic cortex-striatum-substantia nigra cultures from rat that indeed striatal neurons respond to cortical avalanches originating in superficial layers. We simultaneously recorded spontaneous local field potentials (LFPs) in the cortical and striatal tissue using high-density microelectrode arrays. In the cortex, spontaneous neuronal avalanches were characterized by intermittent spatiotemporal activity clusters with a cluster size distribution that followed a power law with exponent 1.5. In the striatum, intermittent spatiotemporal activity was found to correlate with cortical avalanches. However, striatal negative LFP peaks (nLFPs) did not showavalanche signatures, but formed a cluster size distribution that had a much steeper drop-off, i.e., lacked large spatial clusters that are commonly expected for avalanche dynamics. The underlying de-correlation of striatal activity could have its origin in the striatum through local inhibition and/or could result from a particular mapping in the corticostriatal pathway. Here we show, using modeling, that highly convergent corticostriatal projections can map spatially extended cortical activity into spatially restricted striatal regimes.
Place, publisher, year, edition, pages
Springer Netherlands, 2015, 4. 291-297 p.
Neuronal avalanches, Striatum, Cortico-striatal network, Cortex, Basal ganglia
IdentifiersURN: urn:nbn:se:kth:diva-168104DOI: 10.1007/978-94-017-9548-7_41ISI: 000380362800041ISBN: 978-94-017-9547-0OAI: oai:DiVA.org:kth-168104DiVA: diva2:814424
QC 201506232015-05-272015-05-272016-08-12Bibliographically approved