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New paradigms for metabolic modeling of human cells
KTH, Centres, Science for Life Laboratory, SciLifeLab.
2015 (English)In: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 34, 91-97 p.Article in journal (Refereed) Published
Abstract [en]

Abnormalities in cellular functions are associated with the progression of human diseases, often resulting in metabolic reprogramming. GEnome-scale metabolic Models (GEMs) have enabled studying global metabolic reprogramming in connection with disease development in a systematic manner. Here we review recent work on reconstruction of GEMs for human cell/tissue types and cancer, and the use of GEMs for identification of metabolic changes occurring in response to disease development. We further discuss how GEMs can be used for the development of efficient therapeutic strategies. Finally, challenges in integration of cell/tissue models for simulation of whole body functions as well as integration of GEMs with other biological networks for generating complete cell/tissue models are presented.

Place, publisher, year, edition, pages
2015. Vol. 34, 91-97 p.
Keyword [en]
Bioinformatics, Cells, Cytology, Gems, Biological networks, Cellular function, Disease development, Genome scale metabolic model, Human disease, Metabolic changes, Metabolic modeling, Therapeutic strategy, Metabolism, biological model, cell metabolism, disease course, gene expression, human, intestine flora, metabolomics, proteomics, Review, simulation, tissue metabolism, transcriptomics, tumor growth
National Category
Medical Biotechnology
URN: urn:nbn:se:kth:diva-167688DOI: 10.1016/j.copbio.2014.12.013ScopusID: 2-s2.0-84920286423OAI: diva2:816088

QC 20150602

Available from: 2015-06-02 Created: 2015-05-22 Last updated: 2015-06-02Bibliographically approved

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Nielsen, Jens Brehm Bagger
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