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Mean Expected Error in Prediction of Total Body Water: A True Accuracy Comparison between Bioimpedance Spectroscopy and Single Frequency Regression Equations
KTH, School of Technology and Health (STH), Medical Engineering, Medical sensors, signals and systems. Univ Boras, Fac Care Sci Work Life & Social Welfare, Sweden.ORCID iD: 0000-0002-6995-967X
KTH, School of Technology and Health (STH), Medical Engineering, Medical sensors, signals and systems. Karolinska Inst, Dept Clin Sci Intervent & Technol, Sweden.ORCID iD: 0000-0001-7807-8682
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2015 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, 656323Article in journal (Refereed) Published
Abstract [en]

For several decades electrical bioimpedance (EBI) has been used to assess body fluid distribution and body composition. Despite the development of several different approaches for assessing total body water (TBW), it remains uncertain whether bioimpedance spectroscopic (BIS) approaches are more accurate than single frequency regression equations. The main objective of this study was to answer this question by calculating the expected accuracy of a single measurement for different EBI methods. The results of this study showed that all methods produced similarly high correlation and concordance coefficients, indicating good accuracy as a method. Even the limits of agreement produced from the Bland-Altman analysis indicated that the performance of single frequency, Sun’s prediction equations, at population level was close to the performance of both BIS methods; however, when comparing the Mean Absolute Percentage Error value between the single frequency prediction equations and the BIS methods, a significant difference was obtained, indicating slightly better accuracy for the BIS methods. Despite the higher accuracy of BIS methods over 50 kHz prediction equations at both population and individual level, the magnitude of the improvement was small. Such slight improvement in accuracy of BIS methods is suggested insufficient to warrant their clinical use where the most accurate predictions of TBW are required, for example, when assessing over-fluidic status on dialysis. To reach expected errors below 4-5%, novel and individualized approaches must be developed to improve the accuracy of bioimpedance-based methods for the advent of innovative personalized health monitoring applications.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2015. 656323
Keyword [en]
Bioimpedance Spectroscopy, Body Composition Analysis, Total Body Water, Hanai-Mixture Theory, Volume Prediction Equations
National Category
Signal Processing Other Medical Engineering Medical and Health Sciences Urology and Nephrology
URN: urn:nbn:se:kth:diva-168444DOI: 10.1155/2015/656323ISI: 000356307300001OAI: diva2:816699

QC 20150618

Available from: 2015-06-03 Created: 2015-06-03 Last updated: 2015-07-03Bibliographically approved

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