Change search
ReferencesLink to record
Permanent link

Direct link
RhoD is a Golgi component with a role in anterograde protein transport from the ER to the plasma membrane
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-5584-9170
Show others and affiliations
2015 (English)In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 333, no 2, 208-219 p.Article in journal (Refereed) Published
Abstract [en]

RhoD is a member of the Rho GTPase family and it coordinates actin dynamics and membrane trafficking. Activation of RhoD results in formation of filopodia, dissolution of stress fibers, and the subsequent formation of short actin bundles. In addition, RhoD localizes to early endosomes and recycling endosomes, and has a regulatory role in endosome trafficking. In this study, we report on a function of RhoD in the regulation of Golgi homeostasis. We show that manipulation of protein and activation levels of RhoD, as well as of its binding partner WHAMM, result in derailed localization of Golgi stacks. Moreover, vesicle trafficking from the endoplasmic reticulum to the plasma membrane via the Golgi apparatus measured by the VSV-G protein is severely hampered by manipulation of RhoD or WHAMM. In summary, our studies demonstrate a novel role for this member of the Rho GTPases in the regulation of Golgi function.

Place, publisher, year, edition, pages
2015. Vol. 333, no 2, 208-219 p.
Keyword [en]
Golgi, Rho GTPases, RhoD, VSV-G, WHAMM
National Category
Cell Biology
URN: urn:nbn:se:kth:diva-166900DOI: 10.1016/j.yexcr.2015.02.023ISI: 000353666100009PubMedID: 25746724ScopusID: 2-s2.0-84927911493OAI: diva2:818791
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish Cancer Society, 110549Swedish Research Council, K201066P20582044The Karolinska Institutet's Research Foundation

QC 20150609

Available from: 2015-06-09 Created: 2015-05-21 Last updated: 2015-06-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Blom, Hans
By organisation
Cell PhysicsScience for Life Laboratory, SciLifeLab
In the same journal
Experimental Cell Research
Cell Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 25 hits
ReferencesLink to record
Permanent link

Direct link