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Foil-based DNA melting curve analysis platform for low-cost point-of-care molecular diagnostics
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.ORCID iD: 0000-0001-5199-0663
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
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2013 (English)In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 2013, Vol. 3, 1770-1772 p.Conference paper, Published paper (Refereed)
Abstract [en]

We report on genotyping of single nucleotide polymorphisms (SNP) by melting curve analysis (MCA) on DNA microarrays in a plastic microfluidic system with integrated heaters using lamination foils. Thin-film micro-heaters were processed on polyethylene napthalate (PEN) foil in only one metallization step. DNA microarrays were prepared directly on the PEN surface without the need of surface pre-treatment via UV-mediated immobilization of the spotted DNA microarrays. MCA in microfluidic channels is demonstrated at a ramping rate of 60°C/min, enabling ultra-rapid (50 seconds) SNP analysis.

Place, publisher, year, edition, pages
2013. Vol. 3, 1770-1772 p.
Keyword [en]
Lab-on-chip, Micro-heater, Microarray, Single nucleotide polymorphism
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-168797Scopus ID: 2-s2.0-84907307461ISBN: 978-163266624-6 (print)OAI: oai:DiVA.org:kth-168797DiVA: diva2:819658
Conference
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Freiburg; Germany
Note

QC 20150611

Available from: 2015-06-11 Created: 2015-06-09 Last updated: 2015-06-11Bibliographically approved

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