Contact-active antibacterial multilayers on fibres: a step towards understanding the antibacterial mechanism by increasing the fibre charge
2015 (English)In: Cellulose (London), ISSN 0969-0239, E-ISSN 1572-882X, Vol. 22, no 3, 2023-2034 p.Article in journal (Refereed) Published
Contact-active antibacterial materials with irreversibly attached antibacterial agents have been developed as an environmentally friendly alternative to traditional biocide treatments. Of particular interest are materials fabricated through the physical adsorption of charged polymers. This simple method allows for the use of water-based processes and materials originating from renewable sources, e.g., cellulosic fibres. Furthermore, by varying the process parameters, such as ionic strength, it is possible to tune the properties of the adsorbed polymer layer. However, the underlying antibacterial mechanism remains obscure, and this hinders the rational design of antibacterial multilayers. To gain further insight into the antibacterial mechanisms of physically adsorbed multilayers of polyvinylamine and polyacrylic acid, the surface charge of cellulose fibres was increased via radical oxidation. This oxidation increased the amount of polymer that was adsorbed and resulted in increased antibacterial efficacy against both Escherichia coli and Bacillus subtilis compared with polymer-modified unoxidised fibres. Electron microscopy analysis of the E. coli adhered to the fibres revealed that the multilayer treatment resulted in elongated bacteria with deformed cell walls. This work demonstrates the importance of electrostatic interaction to the antibacterial effect of polymer-modified fibres.
Place, publisher, year, edition, pages
2015. Vol. 22, no 3, 2023-2034 p.
Antibacterial materials, Contact-active, Antibacterial cellulose, Antibacterial mechanism, Polyvinylamine, Polyelectrolyte multilayers, Layer-by-layer, Polymer adsorption
IdentifiersURN: urn:nbn:se:kth:diva-169246DOI: 10.1007/s10570-015-0629-8ISI: 000354193000044OAI: oai:DiVA.org:kth-169246DiVA: diva2:822021
QC 201506162015-06-162015-06-122015-06-16Bibliographically approved