Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery
2015 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 51, no 48, 9833-9836 p.Article in journal (Refereed) Published
A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.
Place, publisher, year, edition, pages
2015. Vol. 51, no 48, 9833-9836 p.
Silica Nanoparticles, Controlled-Release, Concanavalin-A, Nanocontainers, Nanocarriers, Biocompatibility, Covalent, Glucose, System, Cancer
IdentifiersURN: urn:nbn:se:kth:diva-169982DOI: 10.1039/c5cc02907dISI: 000355631700017PubMedID: 25989158ScopusID: 2-s2.0-84930636671OAI: oai:DiVA.org:kth-169982DiVA: diva2:826480
QC 201506252015-06-252015-06-252015-08-13Bibliographically approved