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Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery
KTH, School of Chemical Science and Engineering (CHE), Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry. University of Massachusetts, United States.
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2015 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 51, no 48, 9833-9836 p.Article in journal (Refereed) Published
Abstract [en]

A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.

Place, publisher, year, edition, pages
2015. Vol. 51, no 48, 9833-9836 p.
Keyword [en]
Silica Nanoparticles, Controlled-Release, Concanavalin-A, Nanocontainers, Nanocarriers, Biocompatibility, Covalent, Glucose, System, Cancer
National Category
Chemical Sciences
URN: urn:nbn:se:kth:diva-169982DOI: 10.1039/c5cc02907dISI: 000355631700017PubMedID: 25989158ScopusID: 2-s2.0-84930636671OAI: diva2:826480

QC 20150625

Available from: 2015-06-25 Created: 2015-06-25 Last updated: 2015-08-13Bibliographically approved
In thesis
1. Multifunctional Glyconanomaterials: Applications in Biorecognition and Drug Delivery
Open this publication in new window or tab >>Multifunctional Glyconanomaterials: Applications in Biorecognition and Drug Delivery
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis consists of three parts, which revolve around the fabrication of multifunctional glyconanomaterials (cellulose nanocrystals, chitin nanocrystals, mesoporous silica nanoparticles) and the development of their applications in biorecognition and nanomedicine.

Part one presents a detailed introduction to glyconanomaterials, focusing on cellulose nanocrystals, chitin nanocrystals and mesoporous silica nanoparticles, including their general preparations, properties and applications.

Part two demonstrates dually modified cellulose and chitin nanocrystals. They are prepared by TEMPO-mediated oxidation, followed by conjugation with a fluorescent dye and carbohydrate ligands. The two functional nanocrystals are applied in carbohydrate-lectin recognition and bacterial imaging as new types of glyconanomaterials.

Part three describes two types of drug delivery systems based on carbohydrate- conjugated mesoporous silica nanoparticles: the first type is a trehalose- functionalized nanoparticle which can selectively recognize mycobacteria, release antimicrobial drugs and kill them; the second type is a lectin-gated drug container, which can perform controlled delivery of drugs to cancer cells in response to glutathione.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2015. 70 p.
TRITA-CHE-Report, ISSN 1654-1081 ; 2015:28
glyconanomaterials, cellulose nanocrystals, chitin nanocrystals, mesoporous silica nanoparticles, lectin, biorecognition, drug delivery, bacteria, cytotoxicity, perfluorophenylazide, fluorescent dye, carbohydrate ligands.
National Category
Nano Technology
urn:nbn:se:kth:diva-171951 (URN)978-91-7595-570-4 (ISBN)
Public defence
2015-09-04, B2, Brinellvägen 23, KTH, Stockholm, 13:00 (English)

QC 20150813

Available from: 2015-08-13 Created: 2015-08-10 Last updated: 2015-08-13Bibliographically approved

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