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Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent
KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits. Petrozavodsk State University, Russian Federation .ORCID iD: 0000-0002-4997-9032
KTH, School of Information and Communication Technology (ICT), Integrated Devices and Circuits. INMATECH Intelligent Materials Technology, Sweden.
2015 (English)In: AIP Advances, ISSN 2158-3226, E-ISSN 2158-3226, Vol. 5, no 5, 057104Article in journal (Refereed) Published
Abstract [en]

Continuous bead-free C-type cubic gadolinium oxide (Gd2O3) nanofibers 20-30 mu m long and 40-100 nm in diameter were sintered by sol-gel calcination assisted electrospinning technique. Dipole-dipole interaction of neighboring Gd3+ ions in nanofibers with large length-to-diameter aspect ratio results in some kind of superparamagnetic behavior: fibers are magnetized twice stronger than Gd2O3 powder. Being compared with commercial Gd-DTPA/Magnevist (R), Gd2O3 diethyleneglycol-coated (Gd2O3-DEG) fibers show high 1/T-1 and 1/T-2 proton relaxivities. Intense room temperature photoluminescence, high NMR relaxivity and high neutron scattering cross-section of Gd-157 nucleus promise to integrate Gd2O3 fibers for multimodal bioimaging and neutron capture therapy.

Place, publisher, year, edition, pages
2015. Vol. 5, no 5, 057104
Keyword [en]
Contrast Agents, Nanoparticles
National Category
Materials Engineering
Identifiers
URN: urn:nbn:se:kth:diva-169970DOI: 10.1063/1.4919810ISI: 000355568100024Scopus ID: 2-s2.0-84928922812OAI: oai:DiVA.org:kth-169970DiVA: diva2:826985
Note

QC 20150626

Available from: 2015-06-26 Created: 2015-06-25 Last updated: 2017-12-04Bibliographically approved

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Grishin, Alexander M.

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