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Epigenome-wide association study of aging using Swedish twin cohort data
KTH, School of Biotechnology (BIO).
2015 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

DNA methylation is an important feature of the aging process. Recent studies have revealed the association between DNA methylation and age. Also, the Methylation patterns of many CpG sites and genes have been reported to be age related. This study aims to study DNA methylation data from midroarray and to perform statistical analysis to identify age-related CpG sites. We processed Swedish twin cohort data from Illumina 450k methylation array and identified 417 significant CpG sites from the Cpigenome-Wide Association Study.

Place, publisher, year, edition, pages
Keyword [en]
epigenetics, aging, genome-wide association analysis, DNA methylation, CpG
National Category
Engineering and Technology
URN: urn:nbn:se:kth:diva-172107OAI: diva2:845712
Available from: 2015-09-10 Created: 2015-08-12 Last updated: 2015-09-10Bibliographically approved

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