Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Intraglomerular Lateral Inhibition Promotes Spike Timing Variability in Principal Neurons of the Olfactory Bulb
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-8044-9195
Show others and affiliations
2015 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 35, no 10, 4319-4331 p.Article in journal (Refereed) Published
Abstract [en]

The activity of mitral and tufted cells, the principal neurons of the olfactory bulb, is modulated by several classes of interneurons. Among them, diverse periglomerular (PG) cell types interact with the apical dendrites of mitral and tufted cells inside glomeruli at the first stage of olfactory processing. We used paired recording in olfactory bulb slices and two-photon targeted patch-clamp recording in vivo to characterize the properties and connections of a genetically identified population of PG cells expressing enhanced yellow fluorescent protein (EYFP) under the control of the Kv3.1 potassium channel promoter. Kv3.1–EYFP+ PG cells are axonless and monoglomerular neurons that constitute ∼30% of all PG cells and include calbindin-expressing neurons. They respond to an olfactory nerve stimulation with a short barrage of excitatory inputs mediated by mitral, tufted, and external tufted cells, and, in turn, they indiscriminately release GABA onto principal neurons. They are activated by even the weakest olfactory nerve input or by the discharge of a single principal neuron in slices and at each respiration cycle in anesthetized mice. They participate in a fast-onset intraglomerular lateral inhibition between principal neurons from the same glomerulus, a circuit that reduces the firing rate and promotes spike timing variability in mitral cells. Recordings in other PG cell subtypes suggest that this pathway predominates in generating glomerular inhibition. Intraglomerular lateral inhibition may play a key role in olfactory processing by reducing the similarity of principal cells discharge in response to the same incoming input.

Place, publisher, year, edition, pages
Society for Neuroscience , 2015. Vol. 35, no 10, 4319-4331 p.
Keyword [en]
Olfaction
National Category
Neurosciences
Research subject
Biological Physics
Identifiers
URN: urn:nbn:se:kth:diva-172326DOI: 10.1523/JNEUROSCI.2181-14.2015ISI: 000352199900020OAI: oai:DiVA.org:kth-172326DiVA: diva2:846684
Note

QC 20150825

Available from: 2015-08-17 Created: 2015-08-17 Last updated: 2017-12-04Bibliographically approved

Open Access in DiVA

fulltext(20703 kB)55 downloads
File information
File name FULLTEXT01.pdfFile size 20703 kBChecksum SHA-512
f95570152ccc073eb13aa681da332148b07120bea3194928b77b9e1206a6d3fdb288327d5f10789da3945701384eefaba3a5a455563c9b7460dba5fcefe567c9
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Kumar, ArvindDe Saint Jan, Didier

Search in DiVA

By author/editor
Kumar, ArvindDe Saint Jan, Didier
By organisation
Computational Biology, CB
In the same journal
Journal of Neuroscience
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 55 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 155 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf