The Carbocation: A Forgotten Lewis Acid Catalyst
2015 (English)In: ChemCatChem, ISSN 1867-3880, E-ISSN 1867-3899, Vol. 7, no 13, 1896-1905 p.Article in journal (Refereed) Published
A Lewis acid that has received negligible attention as a catalyst is the carbocation. The carbocation is isoelectronic to boron and owes its Lewis acidity to a low-lying empty p(C) orbital. In terms of reactivity and stability carbocations are very versatile Lewis acids, from the extremely unstable methylium cation to the water-stable tris(N,N-dimethylaniline) methylium ion (crystal violet). Although the Lewis acid properties of carbocations have been extensively studied since the discovery of the tropolium ion more than 130years ago there is only a handful examples on the application of carbocations as Lewis acid catalysts. Herein, the research on triarylmethylium (trityl)-cation catalysis is summarized. In light of the reports the trityl ion emerges as a highly efficient and highly versatile Lewis acid catalyst capable of catalyzing different classes of reactions often with high selectivity and low catalyst loadings (for some reactions down to ppm levels).
Place, publisher, year, edition, pages
2015. Vol. 7, no 13, 1896-1905 p.
aldol reaction, carbocations, Diels-Alder reaction, Lewis acids, organocatalysis
IdentifiersURN: urn:nbn:se:kth:diva-172492DOI: 10.1002/cctc.201500225ISI: 000357336400001ScopusID: 2-s2.0-84934290639OAI: oai:DiVA.org:kth-172492DiVA: diva2:848640
FunderSwedish Research CouncilWenner-Gren Foundations
QC 201508252015-08-252015-08-252015-08-25Bibliographically approved