Bio-based production of monomers and polymers by metabolically engineered microorganisms
2015 (English)In: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 36, 73-84 p.Article, review/survey (Refereed) Published
Recent metabolic engineering strategies for bio-based production of monomers and polymers are reviewed. In the case of monomers, we describe strategies for producing polyamide precursors, namely diamines (putrescine, cadaverine, 1,6-diaminohexane), dicarboxylic acids (succinic, glutaric, adipic, and sebacic acids), and ω-amino acids (γ-aminobutyric, 5-aminovaleric, and 6-aminocaproic acids). Also, strategies for producing diols (monoethylene glycol, 1,3-propanediol, and 1,4-butanediol) and hydroxy acids (3-hydroxypropionic and 4-hydroxybutyric acids) used for polyesters are reviewed. Furthermore, we review strategies for producing aromatic monomers, including styrene, p-hydroxystyrene, p-hydroxybenzoic acid, and phenol, and propose pathways to aromatic polyurethane precursors. Finally, in vivo production of polyhydroxyalkanoates and recombinant structural proteins having interesting applications are showcased.
Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 36, 73-84 p.
RECOMBINANT ESCHERICHIA-COLI, GAMMA-AMINOBUTYRATE GABA, SUCCINIC ACID PRODUCTION, MUSSEL ADHESIVE PROTEIN, CORYNEBACTERIUM-GLUTAMICUM, MICROBIAL-PRODUCTION, MANNHEIMIA-SUCCINICIPRODUCENS, PSEUDOMONAS-PUTIDA, CARBON DIAMINE, ADIPIC ACID
Research subject Biotechnology
IdentifiersURN: urn:nbn:se:kth:diva-172801DOI: 10.1016/j.copbio.2015.07.003ISI: 000367116700010ScopusID: 2-s2.0-84940063735OAI: oai:DiVA.org:kth-172801DiVA: diva2:849611
QC 20150831. QC 201601212015-08-292015-08-292016-01-21Bibliographically approved