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Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences
Karolinska Institutet, Sweden.
KTH, School of Information and Communication Technology (ICT), Communication Systems, CoS, Radio Systems Laboratory (RS Lab).ORCID iD: 0000-0002-6066-746X
Karolinska Institutet, Sweden.
Karolinska University Hospital Solna, Sweden.ORCID iD: 0000-0002-5870-2975
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2015 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, 1-11 p., 574705Article in journal (Refereed) Published
Abstract [en]

Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consentto undergo Na18Fβˆ’ PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curveeliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions werecompared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal)bone, and muscle. The SUVπ‘š(𝑑) (π‘š = max, mean) and a series of slopes were computed as (SUVπ‘š(𝑑𝑖) βˆ’ SUVπ‘š(𝑑𝑗))/(𝑑𝑖 βˆ’ 𝑑𝑗), forpairs of time values 𝑑𝑖 and 𝑑𝑗. A Patlak-like analysis was performed for the same time values by computing ((VOI𝑝(𝑑𝑖)/VOI𝑒(𝑑𝑖)) βˆ’(VOI𝑝(𝑑𝑗)/VOI𝑒(𝑑𝑗)))/(π‘‘π‘–βˆ’π‘‘π‘—), where p = broken bone, other bone, andmuscle and e = expected activity in aVOI. Paired comparisonsbetween Patlak-like and SUVπ‘š slopes showed good agreement by both linear regression and correlation coefficient analysis(π‘Ÿ = 84%, π‘Ÿπ‘  = 78%-SUVmax, π‘Ÿ = 92%, and π‘Ÿπ‘  = 91%-SUVmean), suggesting static scans could substitute for dynamic studies.Patlak-like slope differences of 0.1 minβˆ’1 or greater between examinations and SUVmax differences of ∼5 usually indicated goodremodeling progress, while negative Patlak-like slope differences of βˆ’0.06 minβˆ’1 usually indicated poor remodeling progress in thiscohort.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2015. Vol. 2015, 1-11 p., 574705
National Category
Orthopedics Radiology, Nuclear Medicine and Medical Imaging
URN: urn:nbn:se:kth:diva-173247DOI: 10.1155/2015/574705ISI: 000361696200001OAI: diva2:852295

QC 20150910

Available from: 2015-09-08 Created: 2015-09-08 Last updated: 2015-10-20Bibliographically approved

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Maguire Jr., Gerald Q.Jonsson, CathrineNoz, Marilyn E.Zeleznik, Michael P.Jacobsson, HansWeidenhielm, Lars
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Radio Systems Laboratory (RS Lab)
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