Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences
2015 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, 1-11 p., 574705Article in journal (Refereed) Published
Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consentto undergo Na18F− PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curveeliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions werecompared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal)bone, and muscle. The SUV𝑚(𝑡) (𝑚 = max, mean) and a series of slopes were computed as (SUV𝑚(𝑡𝑖) − SUV𝑚(𝑡𝑗))/(𝑡𝑖 − 𝑡𝑗), forpairs of time values 𝑡𝑖 and 𝑡𝑗. A Patlak-like analysis was performed for the same time values by computing ((VOI𝑝(𝑡𝑖)/VOI𝑒(𝑡𝑖)) −(VOI𝑝(𝑡𝑗)/VOI𝑒(𝑡𝑗)))/(𝑡𝑖−𝑡𝑗), where p = broken bone, other bone, andmuscle and e = expected activity in aVOI. Paired comparisonsbetween Patlak-like and SUV𝑚 slopes showed good agreement by both linear regression and correlation coefficient analysis(𝑟 = 84%, 𝑟𝑠 = 78%-SUVmax, 𝑟 = 92%, and 𝑟𝑠 = 91%-SUVmean), suggesting static scans could substitute for dynamic studies.Patlak-like slope differences of 0.1 min−1 or greater between examinations and SUVmax differences of ∼5 usually indicated goodremodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in thiscohort.
Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2015. Vol. 2015, 1-11 p., 574705
Orthopedics Radiology, Nuclear Medicine and Medical Imaging
IdentifiersURN: urn:nbn:se:kth:diva-173247DOI: 10.1155/2015/574705ISI: 000361696200001OAI: oai:DiVA.org:kth-173247DiVA: diva2:852295
QC 201509102015-09-082015-09-082015-10-20Bibliographically approved