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Syntes av bioaktiverade organiska nanomaterial
KTH, School of Chemical Science and Engineering (CHE).
2015 (Swedish)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Development of Bioactivated Organic Nanomaterials (English)
Abstract [sv]

En ny metod för syntes av dendroner baserade på 2,2-

bis(hydroxymethyl)propionic acid (bis-MPA) genom användning av FPE-kemi (fluorine-promoted

esterification chemistry) visas genom syntes av fyra generationers dendron med en bensylskyddad

tetraetylenglykol-kärna. Bensylskyddningen kunde selektivt avlägsnas genom hydrogenering utan att

störa de perifera acetonidskyddningarna, vilket tillät selektiv funktionalisering av kärnan och periferin.

Aminfunktionella bis-MPA-dendrimerer av generation 2, 3 och 4 har även syntetiserats. Deras

nedbrytning i vattenlösningar med olika pH utvärderades och deras toxicitet studerades in vitro.

Dendrimererna visade sig vara bionedbrytbara och visade generationsberoende cytotixicitet.

Abstract [en]

A novel way of synthesizing dendrons based on 2,2-bis(hydroxymethyl)propionic acid

(bis-MPA) using fluorine-promoted esterification (FPE) chemistry is demonstrated through the

synthesis of four generations of a dendron with a benzylated tetraethyelene glycol spacer in the core.

The benzyl protection was removed selectively through hydrogenolysis without interfering with the

peripheral acetonide protections of the dendron, which allowed for selective functionalization with

bioactive functionalities at the core and periphery. Amine functional bis-MPA dendrimers of generation

2, 3 and 4 were also synthesized. Their degradation in aqueous media with various pH was evaluated

and their toxicity was studied in vitro. The dendrimers showed to be biodegradable and to exhibit a

generation dependent and time dependent cytotoxicity.

Place, publisher, year, edition, pages
2015. , 24 p.
Keyword [en]
dendritic materials, bioactiviations, hydrolytical stability, bioactivation
National Category
Polymer Chemistry
URN: urn:nbn:se:kth:diva-173378OAI: diva2:852874
Available from: 2015-09-10 Created: 2015-09-10 Last updated: 2015-09-10Bibliographically approved

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