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Genome-wide analysis of Notch/CSL binding profile in human breast cancer cells
KTH, School of Biotechnology (BIO).
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Notch signaling is a highly conserved signaling pathway important in the transcriptional control expecially during cell fate choice and tumorigenesis. For examplem breast cancer is isusally associated with dysregulated Notch signaling. Therefore, understanding the transcriptional control by Notcvh is fundamental to understand tumor biology of brest cancer. The action of Notch is very contect dependent, but not much is known about the underpinning mechanisms of how different transcriptional controls are achieved. Besides, there were yet to be an accurate genome-wide binding profile of CSL. Here, we have generated CSL null breast cancer cell line and aim to perform accurate binding profile analysis by introducing a tagged version of exogenous CSL. This will shed light on the mechanism of transcriptional control by canonical Notch signaling, ecpecially in the context how it relates to cancer progression in human breast cancer.

Place, publisher, year, edition, pages
Keyword [en]
signaling pathway, cancer, bioinformatics, receptor, transcriptome
National Category
Engineering and Technology
URN: urn:nbn:se:kth:diva-173728OAI: diva2:854686
Available from: 2015-09-18 Created: 2015-09-17 Last updated: 2015-09-18Bibliographically approved

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