Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
2015 (English)In: Cell Metabolism, ISSN 1550-4131, E-ISSN 1932-7420, Vol. 22, no 3, 408-417 p.Article in journal (Refereed) Published
Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone marrow (BM)-derived progenitor cells may contribute to mammalian adipogenesis; however, results in animal models are conflicting. Here we demonstrate in 65 subjects who underwent allogeneic BM or peripheral blood stem cell (PBSC) transplantation that, over the entire lifespan, BM/PBSC-derived progenitor cells contribute similar to 10% to the subcutaneous adipocyte population. While this is independent of gender, age, and different transplantation-related parameters, body fat mass exerts a strong influence, with up to 2.5-fold increased donor cell contribution in obese individuals. Exome and whole-genome sequencing of single adipocytes suggests that BM/PBSC-derived progenitors contribute to adipose tissue via both differentiation and cell fusion. Thus, at least in the setting of transplantation, BM serves as a reservoir for adipocyte progenitors, particularly in obese subjects.
Place, publisher, year, edition, pages
2015. Vol. 22, no 3, 408-417 p.
Cell Biology Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:kth:diva-173762DOI: 10.1016/j.cmet.2015.06.011ISI: 000360453900013PubMedID: 26190649ScopusID: 2-s2.0-84940718419OAI: oai:DiVA.org:kth-173762DiVA: diva2:855910
FunderSwedish Diabetes AssociationSwedish Cancer SocietySwedish Research CouncilNovo Nordisk